Stressor: 661
Title
Nitric oxide
Stressor Overview
AOPs Including This Stressor
Events Including This Stressor
Chemical Table
User term | DTXID | Preferred name | Casrn | jchem_inchi_key | indigo_inchi_key |
---|---|---|---|---|---|
Nitric oxide | DTXSID1020938 | Nitric oxide | 10102-43-9 | MWUXSHHQAYIFBG-UHFFFAOYSA-N | MWUXSHHQAYIFBG-UHFFFAOYSA-N |
AOP Evidence
Event Evidence
Mucociliary Clearance, Decreased
In New Zealand white rabbits exposed to 3 ppm NO2 for 24 h, the average CBF decreased from 764 beats/min to 692 beats/min and the transport velocity decreased from 5.23 mm/min to 3.03 mm/min (Kakinoki, 1998).
Decrease, Lung function
In a Dutch cross-sectional study in school children (aged 7–13 years), NOx exposure from industrial emissions per interquartile range of 7.43 μg/m3 had a significantly lower percent predicted peak expiratory flow (PEF) (-3.67%, 95%CI -6.93% to -0.42%). Children exposed to NOx (per interquartile range of 7.43 μg/m3) also had a significantly lower percent forced vital capacity (FVC) and percent predicted 1-s forced expiratory volume (FEV1) (− 2.73 95%CI -5.21 to -0.25) (Bergstra et al., 2018).
The European Study of Cohorts for Air Pollution Effects (ESCAPE), a meta-analysis of 5 cohort studies on the association of air pollution with lung function, found that a 10 μg/m3 increase in NO2 exposure was associated with lower levels of FEV1 (−14.0 mL, 95% CI −25.8 to −2.1) and FVC (−14.9 mL, 95% CI −28.7 to −1.1), and an increase of 20 μg/m3 in NOx exposure was associated with a lower level of FEV1, by −12.9 mL (95% CI −23.87 to −2.0) and of FVC, by −13.3 mL (95% CI −25.9 to −0.7) (Adam et al., 2015).
Chronic, Mucus hypersecretion
At the individual level, self‐reported traffic intensity and home outdoor levels of NO2 (a surrogate of traffic exposure) were associated with frequency of chronic phlegm in females, independent of smoking (Sunyer et al., 2006).