Stressor: 667
Title
Diesel engine exhaust
Stressor Overview
AOPs Including This Stressor
AOP Name | Evidence |
---|---|
Oxidative stress Leading to Decreased Lung Function | Low |
Events Including This Stressor
Event Name |
---|
Decrease, Lung function |
Chemical Table
User term | DTXID | Preferred name | Casrn | jchem_inchi_key | indigo_inchi_key |
---|---|---|---|---|---|
Diesel engine exhaust | DTXSID1024043 | Diesel engine exhaust | NOCAS_24043 |
AOP Evidence
Oxidative stress Leading to Decreased Lung Function
Incubation of human primary bronchial epithelial cells differentiated at the air-liquid interface with Diesel exhaust particles (DEP; 100 µg/mL = 16.26 ng/mL phenanthrene, 3.65 ng/mL fluoranthene, 2.53 ng/mL pyrene) attenuated CBF in a time- and dose-dependent manner. Exposure to 10 µg/mL DEP decreased CBF by 40% (Q1 = 19, Q3 = 46) from baseline after 24-h incubation. Similarly, exposure to 50 µg/mL DEP, filtered DEP solution, or 100 µg/mL DEP decreased CBF by 51% (Q1 = 49, Q3 = 56), 33% (Q1 = 26, Q3 = 36), and 73% (Q1 = 65, Q3 = 83), respectively, from baseline after 24-h incubation. Changes in CBF started to become significant at 4 h with 50 µg/mL DEP and at 2 h with 100 µg/mL DEP compared to untreated cultures (Bayram et al., 1998).
Event Evidence
Decrease, Lung function
In a study of 733 adult females who had lived in the Tokyo metropolitan area for more than 3 years, the higher the level of air pollution, the more significantly the FEV1 was reduced (Sekine et al., 2004).
In a study in 29 healthy subjects, exposure to DE inside diesel-powered trains for 3 days was associated with reduced lung function (Andersen et al., 2019).
In workers who tested diesel engines in an assembly unit of a manufacturing plant, FEV1, FEV1/FVC, FEV25-75 and MEF were significantly reduced compared to non-exposed workers (Zhang et al., 2017).
Stressor Info
Chemical/Category Description
Characterization of Exposure
References
Bayram, H., Devalia, J.L., Sapsford, R.J., Ohtoshi, T., Miyabara, Y., Sagai, M., et al. (1998). The effect of diesel exhaust particles on cell function and release of inflammatory mediators from human bronchial epithelial cells in vitro. Am. J. Respir. Cell Mol. Biol. 18(3), 441-448.