Stressor: 667

Title

Chemical name selected from established chemical ontologies or, depending on the information available, this could also refer to chemical categories (i.e., groups of chemicals with defined structural features known to trigger the MIE). It can also include non-chemical prototypical stressors such as genetic or environmental factors. More help

Diesel engine exhaust

Stressor Overview

A structured data field that can be used to annotate an AOP with standardized terms identifying prototypical stressors known to trigger the MIE(s)/AOP. More help

AOPs Including This Stressor

This table is automatically generated and lists the AOPs associated with this prototypical stressor. More help

AOP Name	Evidence
Oxidative stress Leading to Decreased Lung Function	Low
Interaction with lung resident cell membrane components leads to lung cancer	High

Chemical Table

A list of chemicals associated with a prototypical stressor. More help

User term	DTXID	Preferred name	Casrn	jchem_inchi_key	indigo_inchi_key
Diesel engine exhaust	DTXSID1024043	Diesel engine exhaust	NOCAS_24043

References

List of the literature that was cited for this prototypical stressor. More help

Bayram, H., Devalia, J.L., Sapsford, R.J., Ohtoshi, T., Miyabara, Y., Sagai, M., et al. (1998). The effect of diesel exhaust particles on cell function and release of inflammatory mediators from human bronchial epithelial cells in vitro. Am. J. Respir. Cell Mol. Biol. 18(3), 441-448.