Stressor: 711
Title
Silver
Stressor Overview
AOPs Including This Stressor
Events Including This Stressor
Chemical Table
User term | DTXID | Preferred name | Casrn | jchem_inchi_key | indigo_inchi_key |
---|---|---|---|---|---|
Silver | DTXSID4024305 | Silver | 7440-22-4 | BQCADISMDOOEFD-UHFFFAOYSA-N | BQCADISMDOOEFD-UHFFFAOYSA-N |
AOP Evidence
Event Evidence
Inhibition, Mitochondrial Electron Transport Chain Complexes
In Miyayama et al.’s (2013) study on the impact of silver treatment on rat livers they found silver dose-dependant inhibition of electron transport chain complexes at low concentrations. Complexes I to IV all showed inhibition, with CIII showing the most inhibition, followed by CI, CIV, and complex II when treated with 0.01, 0.1, 1.0, and 10 µM, respectively (Miyayama et al., 2013).
Increase, Oxidative Stress
Miyayama et al. (2013) investigated the effects of silver treatment on human bronchial epithelial cells and found that intracellular ROS generation was increased significantly in a dose-dependant manner when treated with 0.01 to 1.0 μM of silver nitrate.
Oxidative Stress
Miyayama et al. (2013) investigated the effects of silver treatment on human bronchial epithelial cells and found that intracellular ROS generation was increased significantly in a dose-dependant manner when treated with 0.01 to 1.0 μM of silver nitrate.
Increase, Cytotoxicity (renal tubular cell)
Miyayama et al. (2013) investigated the effects of silver treatment on human lung epithelial cells and found that silver showed a dose dependant decrease in viability which was significant between the doses 5 and 100 μM.