AOPs Including This Stressor
Events Including This Stressor
|User term||DTXID||Preferred name||Casrn||jchem_inchi_key||indigo_inchi_key|
Sprekelmeyer et al. (2017) conducted a study where they observed the histological changes in rat kidneys treated with gold complexes (Au(III)). They found that the kidney slices treated with the gold complexes for 24 hours showed dose-independent damage in multiple cellular structures in the cortex, with the majority of the damage selectively occurring in the distal tubular cells (Spreckelmeyer et al., 2017).
In their study of the effects of gold (III) treatment on rat kidney cells, Sprekelmeyer et al. (2017) found that the treated kidneys showed a dose-dependant decrease in viability when treated with 0 to 10 μM. The IC50 value determined for gold in this study was 4.3 μM (Spreckelmeyer et al., 2017).