Stressor: 9

Title

Chemical name selected from established chemical ontologies or, depending on the information available, this could also refer to chemical categories (i.e., groups of chemicals with defined structural features known to trigger the MIE). It can also include non-chemical prototypical stressors such as genetic or environmental factors. More help

Allyl Alcohol

Stressor Overview

A structured data field that can be used to annotate an AOP with standardized terms identifying prototypical stressors known to trigger the MIE(s)/AOP. More help

AOPs Including This Stressor

This table is automatically generated and lists the AOPs associated with this prototypical stressor. More help

AOP Name	Evidence
Protein Alkylation leading to Liver Fibrosis	High

Chemical Table

A list of chemicals associated with a prototypical stressor. More help

Preferred name	DTXID	Casrn	jchem_inchi_key	indigo_inchi_key	User term
Allyl alcohol	DTXSID8020044	107-18-6	XXROGKLTLUQVRX-UHFFFAOYSA-N	XXROGKLTLUQVRX-UHFFFAOYSA-N	allyl alcohol

References

List of the literature that was cited for this prototypical stressor. More help

Auerbach SS, Mahler J, Travlos GS, Irwin RD. A comparative 90-day toxicity study of allyl acetate, allyl alcohol and acrolein. Toxicology. 2008 Nov 20;253(1-3):79-88.

Huang L, Heinloth AN, Zeng ZB, Paules RS, Bushel PR. Genes related to apoptosis predict necrosis of the liver as a phenotype observed in rats exposed to a compendium of hepatotoxicants. BMC Genomics. 2008 Jun 16;9:288.

Kehrer JP, Biswal SS. The molecular effects of acrolein. Toxicol Sci. 2000 Sep;57(1):6-15.

Jung SA, Chung YH, Park NH, Lee SS, Kim JA, Yang SH, et al. Experimental model of hepatic fibrosis following repeated periportal necrosis induced by allylalcohol. Scand J Gastroenterol. 2000 Sep;35(9):969-75.

Mohammad MK, Avila D, Zhang J, Barve S, Arteel G, McClain C, et al. Acrolein cytotoxicity in hepatocytes involves endoplasmic reticulum stress, mitochondrial dysfunction and oxidative stress. Toxicol Appl Pharmacol. 2012 Nov 15;265(1):73-82.

Yamada T, Tanaka Y, Hasegawa R, Sakuratani Y, Yamada J, Kamata E, et al. A category approach to predicting the repeated-dose hepatotoxicity of allyl esters. Regul Toxicol Pharmacol. 2013 Mar;65(2):189-95.