Key Event Components

  • Key Event Components (KECs) are used to describe Key Events (KEs) in a computable way, by defining an action, processes, and object term that maps to controlled vocabulary and ontology terms.
  • KECs on this page can be filtered by the action, process, and object terms, as well as by source ontologies.
  • Link to source ontology terms are provided in cases where the URL was available when the ontology terms were added to the AOP-Wiki database.
  • A complete list of all KECs is available in TSV format on the Downloads Page.
Showing 976 to 986 of 986 KECs
Clear Table Filters
ID Action Process Object Associated Key Events (KEs)
976 disrupted regulation of gene expression (GO:0010468) 2224: Dysregulation of transcriptional expression within PPAR signaling network
977 disrupted lipid storage (GO:0019915) 2225: Disrupted Lipid Storage
978 increased vasoconstriction (GO:0042310) kidney afferent arteriole smooth muscle cell (CL:1001097) 2230: Increased, afferent artery vasoconstriction
979 increased positive regulation of translation (GO:0045727) cytochrome P450 (CHEBI:38559) None
980 decreased neuropathy target esterase (PR:000012946) 2243: Neuropathy target esterase, inhibited
981 increased lysophosphatidylcholine (CHEBI:60479) 2244: Lysolecithin, increased
982 increased cell death (GO:0008219) oligodendrocyte (CL:0000128) 2246: Oligodendrocyte death, increased
983 increased demyelination (MP:0000921) 2247: Demyelination, increased
984 increased CNS demyelination (HP:0007305) 2247: Demyelination, increased
985 increased cell death (GO:0008219) cell (GO:0005623) 1829: Altered, Thyroid hormone-dependent gene expression
986 increased cell death (GO:0008219) bone cell (CL:0001035) 1825: Increase, Cell death