This AOP is licensed under a Creative Commons Attribution 4.0 International License.
Elevated ATP demand for detoxification and repair mechanisms leading to impaired locomotor activity
Point of Contact
- Christopher Goodchild
- Evgeniia Kazymova
|Author status||OECD status||OECD project||SAAOP status|
|Under development: Not open for comment. Do not cite|
This AOP was last modified on July 16, 2022 18:37
The oxygen demand needed to facilitate elevated macromolecule catabolism and oxidative phosphorylation at the cellular level may alter energy allocation at the whole-organism level, causing impaired locomotor performance. For instance, contaminants that elevate oxygen demand for basal metabolism may reduce an organism's aerobic scope (i.e., [maximum metabolic rate - basal metabolic rate]) and reduced aerobic can impair locomotor performance.