API XML

Aop: 98

AOP Title

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5-hydroxytryptamine transporter (5-HTT; SERT) inhibition leading to decreased shelter seeking and increased predation

Short name:

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5-HTT block to incr. predation

Graphical Representation

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Click to download graphical representation template

Authors

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Bryan Brooks, Baylor University, USA

Kellie Fay, US EPA

Ksenia Groh, EAWAG, Switzerland

Point of Contact

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Agnes Aggy   (email point of contact)

Contributors

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  • Ksenia Groh
  • Agnes Aggy

Status

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Author status OECD status OECD project SAAOP status
Under development: Not open for comment. Do not cite 1.29 Under Development


This AOP was last modified on February 24, 2018 21:50

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Revision dates for related pages

Page Revision Date/Time
Inhibition, 5-hydroxytryptamine transporter (5-HTT; SERT) September 16, 2017 10:15
Increased, serotonin (5-HT) September 16, 2017 10:15
Decreased, anxiety December 03, 2016 16:37
Decreased, sheltering December 03, 2016 16:37
Increased, predation December 03, 2016 16:37
Increased, serotonin (5-HT) leads to Decreased, anxiety December 03, 2016 16:37
Decreased, anxiety leads to Decreased, sheltering December 03, 2016 16:37
Inhibition, 5-hydroxytryptamine transporter (5-HTT; SERT) leads to Increased, serotonin (5-HT) December 03, 2016 16:37
Decreased, sheltering leads to Increased, predation December 03, 2016 16:37

Abstract

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Thiol (SH)- and seleno-containing proteins are located in different organelles and in the cytoplasm of the different neural cell types (Comini, 2016; Hoppe et al. 2008; Barbosa et al. 2017; Zhu et al. 2017). Binding of chemicals to these proteins induces either their inactivation or favor their degradation and/or inhibition of their synthesis (Farina et al. 2009; Zemolin et al. 2012). Therefore, we will directly include in the description of this MIE the main chemicals (mercury, acrylamide and acrolein) able to bind and to interfere with these proteins.


 


Background (optional)

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Summary of the AOP

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Events: Molecular Initiating Events (MIE)

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Key Events (KE)

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Adverse Outcomes (AO)

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Sequence Type Event ID Title Short name
1 MIE 619 Inhibition, 5-hydroxytryptamine transporter (5-HTT; SERT) Inhibition, 5-hydroxytryptamine transporter (5-HTT; SERT)
2 KE 626 Increased, serotonin (5-HT) Increased, serotonin (5-HT)
3 KE 627 Decreased, anxiety Decreased, anxiety
4 KE 629 Decreased, sheltering Decreased, sheltering
5 AO 588 Increased, predation Increased, predation

Relationships Between Two Key Events
(Including MIEs and AOs)

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Title Adjacency Evidence Quantitative Understanding
Inhibition, 5-hydroxytryptamine transporter (5-HTT; SERT) leads to Increased, serotonin (5-HT) adjacent
Increased, serotonin (5-HT) leads to Decreased, anxiety non-adjacent
Decreased, anxiety leads to Decreased, sheltering non-adjacent
Decreased, sheltering leads to Increased, predation non-adjacent

Network View

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Stressors

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Life Stage Applicability

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Taxonomic Applicability

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Term Scientific Term Evidence Link
Pimephales promelas Pimephales promelas NCBI
Echinogammarus marinus Gammarus marinus NCBI

Sex Applicability

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Overall Assessment of the AOP

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This putative AOP is based on a few studies in fish and mollusks and should be considered preliminary only.

Domain of Applicability

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Essentiality of the Key Events

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Evidence Assessment

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Quantitative Understanding

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Considerations for Potential Applications of the AOP (optional)

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References

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