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Key Event Title
Altered, Gene Expression
|Level of Biological Organization|
Key Event Components
Key Event Overview
AOPs Including This Key Event
|AOP Name||Role of event in AOP||Point of Contact||Author Status||OECD Status|
|ER activation to breast cancer||KeyEvent||Brendan Ferreri-Hanberry (send email)||Open for adoption|
|HDAC inhibition leads to neural tube defects||KeyEvent||Allie Always (send email)||Under Development: Contributions and Comments Welcome|
Key Event Description
It is well documented that alterations of histone acetylation have an impact on gene expression. Therefore if the acetylation status of the epigenetic set-up at the regulatory sequences of genes is altered, this leads to changes in gene expression.
How It Is Measured or Detected
Gene specific alterations in histone acetylation at gene regulatory seqences can be measured by chromatin immunoprecipitation (ChIPs) and gene expression analysis by RT-qPCR or whole transcriptomics (RNAseq, gene chips).