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Key Event Title
neurogenic inflammation of sensory nerves
Key Event Components
Key Event Overview
AOPs Including This Key Event
Key Event Description
C-fibres are understood to mediate adaptive cough responses in pathologic conditions, making them the likely neuronal basis of cough hypersensitivity.
How It Is Measured or Detected
Domain of Applicability
Evidence from human studies is lacking. Patients with idiopathic persistent cough had significantly higher calcitonin-gene-related peptide (CGRP)-containing nerve density in idiopathic cough patients.
Song, W.-J., & Chang, Y.-S. (2015). Cough hypersensitivity as a neuro-immune interaction. Clinical and Translational Allergy, 5(1), 24. doi:10.1186/s13601-015-0069-4