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Key Event Title
Key Event Components
Key Event Overview
AOPs Including This Key Event
|AOP Name||Role of event in AOP||Point of Contact||Author Status||OECD Status|
|Mitochondrial complex inhibition leading to liver injury||AdverseOutcome||Arthur Author (send email)||Under development: Not open for comment. Do not cite|
|IKK complex inhibition leading to liver injury||AdverseOutcome||Brendan Ferreri-Hanberry (send email)||Under development: Not open for comment. Do not cite|
Key Event Description
Taxa = necrotic tissue in the liver
During the process of towards necrotic tissue, too many cells die. In practice it is difficult to distinguish separate forms of cell death (apoptosis, necrosis and necroptosis), especially in vivo.
How It Is Measured or Detected
Histopathology: performed on tissue sections
· Hematoxylin (nuclei) and eosin staining: determine morphology
· TUNEL staining: cell death
(Weng et al. 2015)
(Guicciardi et al. 2013)
Domain of Applicability
Regulatory Significance of the Adverse Outcome
Guicciardi, M.E. et al., 2013. Apoptosis and Necrosis in the Liver. Comprehensive Physiology, 3(2), pp.977–1010. Available at: http://www.pubmedcentral.nih.gov/articlerender.fcgi?artid=3867948&tool=pmcentrez&rendertype=abstract.
Weng, H. et al., 2015. Two sides of one coin: Massive hepatic necrosis and progenitor cell-mediated regeneration in acute liver failure. Frontiers in Physiology, 6(MAY), pp.1–12.