To the extent possible under law, AOP-Wiki has waived all copyright and related or neighboring rights to KE:1759
Event: 1759
Key Event Title
Increase, Cripto-1 expression
Short name
Biological Context
Level of Biological Organization |
---|
Cellular |
Cell term
Organ term
Key Event Components
Process | Object | Action |
---|---|---|
gene expression | teratocarcinoma-derived growth factor 1 | increased |
Key Event Overview
AOPs Including This Key Event
AOP Name | Role of event in AOP | Point of Contact | Author Status | OECD Status |
---|---|---|---|---|
GR Agonism Leading to Impaired Fin Regeneration | KeyEvent | Brendan Ferreri-Hanberry (send email) | Open for citation & comment |
Taxonomic Applicability
Term | Scientific Term | Evidence | Link |
---|---|---|---|
zebrafish | Danio rerio | Moderate | NCBI |
Life Stages
Life stage | Evidence |
---|---|
Larvae | Moderate |
Sex Applicability
Term | Evidence |
---|---|
Mixed |
Key Event Description
Cripto-1 is responsible for growth factor activity, as well as activin binding on the cell membrane. Cripto-1 may also be referred to as teratocarcinoma-derived growth factor 1, tdgf1, or one-eyed pinhead protein, depending on the species (Uniprot). The cripto-1 protein binds to TGF-B and Activin receptors as a co-receptor which mediates signalling (Ravisankar et al., 2011).
Uniprot ID
How It Is Measured or Detected
Cripto-1 transcripts can be measured via quantitative real-time PCR (Sengupta et al., 2012; Garland et al., 2019).
Domain of Applicability
- Cripto-1 has been measured in different vertebrates with a similar function (Uniprot; see above links)
- The EGF and CFC regions of the protein are highly conserved cross species and provide similar function. However there is fuctional differentiation in mammals compared to that of other species (Ravisankar et al., 2011).
References
Garland MA, Sengupta S, Mathew LK, Truong L, Jong ED, Piersma AH, Du JL, Tanguay RL. 2019. Glucocorticoid receptor-dependent induction of cripto-1 (one-eyed pinhead) inhibits zebrafish caudal fin regeneration. Toxicology Reports 6:529-537. https://doi.org/10.1016/j.toxrep.2019.05.013
Ravisankar V, Signh TP, Manoj N. 2011. Molecular evolution of the EGF-CFC protein family. Gene, 428:43-50. doi:10.1016/j.gene.2011.05.007