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Key Event Title
Decreased, Mitochondrial fatty acid beta-oxidation
|Level of Biological Organization|
Key Event Components
|fatty acid beta-oxidation||fatty acid||decreased|
Key Event Overview
AOPs Including This Key Event
|AOP Name||Role of event in AOP||Point of Contact||Author Status||OECD Status|
|Peroxisomal Fatty Acid Beta-Oxidation Inhibition Leading to Steatosis||KeyEvent||Evgeniia Kazymova (send email)||Under Development: Contributions and Comments Welcome|
|PXR activation to steatosis||KeyEvent||Cataia Ives (send email)||Under Development: Contributions and Comments Welcome|
|Homo sapiens||Homo sapiens||High||NCBI|
Key Event Description
Fatty acid oxidation in liver tissue is controlled by PPARalpha signaling networks (Evans et al 2004). The PPARalpha signaling network controls expression of the genes within metabolic pathways that catalyze fatty acid oxidation reactions (Desvergne and Wahli 1999).
How It Is Measured or Detected
A variety of approaches establishing the effects of PPARalpha signaling on fatty acid oxidation are reviewed in Evans et al (2004).
Domain of Applicability
See review for Human PPARalpha signaling in (Evans et al 2004).
Desvergne B, Wahli W (1999) Peroxisome proliferator-activated receptors: nuclear control of metabolism. Endocrine Reviews 20(5): 649-688.
Evans RM, Barish GD, Wang YX: PPARs and the complex journey to obesity. Nat Med 2004, 10(4):355-361.