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Key Event Title
Inhibition, HMG-CoA reductase
|Level of Biological Organization|
Key Event Components
|hydroxymethylglutaryl-CoA reductase activity||3-hydroxy-3-methylglutaryl-coenzyme A reductase||decreased|
Key Event Overview
AOPs Including This Key Event
Key Event Description
How It Is Measured or Detected
The activity of HMG-CoA reductase inhibition may be measured by a commercially available kit which measures a decrease in absorbance at 340 nm, which represents the oxidation of NADPH by the catalytic subunit of HMGR in the presence of the substrate HMG-CoA. Sterol Regulatory element-binding factor 1 (SREBF) is the transcription factor controlling downstream regulation of HMG-CoA reductase. The ToxCast assay ATG_SREBF1_CIS_up is one method of measuring transcriptional control of HMG-CoA reductase.