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All Key Events

Showing 251 to 275 of 1781 Key Events

ID	Title	Event Component Count	Biological Organization	Created At	Last Updated	AOPs

495	Repressed expression of steroidogenic enzymes Short Name	1	Cellular	Nov 29, 2016	Sep 16, 2017	64: Glucocorticoid Receptor (GR) Mediated Adult Leydig Cell Dysfunction Leading to Decreased Male Fertility
496	Increased apoptosis, decreased fetal/adult Leydig Cells Short Name Decreased Leydig Cells	1	Cellular	Nov 29, 2016	May 17, 2023	2 AOPs 64: Glucocorticoid Receptor (GR) Mediated Adult Leydig Cell Dysfunction Leading to Decreased Male Fertility 476: Adverse Outcome Pathways diagram related to PBDEs associated male reproductive toxicity
505	Decreased sperm quantity / quality in the adult, Decreased fertility Short Name	2	Individual	Nov 29, 2016	Dec 3, 2016	3 AOPs 66: Modulation of Adult Leydig Cell Function Subsequent Glucocorticoid Activation in the Fetal Testis 67: Modulation of Adult Leydig Cell Function Subsequent to Estradiaol Activation in the Fetal Testis 68: Modulation of Adult Leydig Cell Function Subsequent to Alterations in the Fetal Testis Protome
520	Decreased sperm quantity or quality in the adult, Decreased fertility Short Name	4	Individual	Nov 29, 2016	Dec 3, 2016	4 AOPs 70: Modulation of Adult Leydig Cell Function Subsequent to Proteomic Alterations in the Adult Leydig Cell 71: Modulation of Adult Leydig Cell Function Subsequent to Glucocorticoid Activation 64: Glucocorticoid Receptor (GR) Mediated Adult Leydig Cell Dysfunction Leading to Decreased Male Fertility 476: Adverse Outcome Pathways diagram related to PBDEs associated male reproductive toxicity
525	Apoptosis of adult Leydig cells, Decreased testosterone by adult Leydig cells Short Name	2	Cellular	Nov 29, 2016	Sep 16, 2017	71: Modulation of Adult Leydig Cell Function Subsequent to Glucocorticoid Activation
526	Inhibition, Inhibition of Dopamine-beta-hydroxylase Short Name	1	Molecular	Nov 29, 2016	Sep 16, 2017	73: Xenobiotic Inhibition of Dopamine-beta-Hydroxylase and subsequent reduced fecundity
527	Decreased, Decreased fecundity Short Name Decreased, Decreased fecundity	2	Individual	Nov 29, 2016	Dec 3, 2016	2 AOPs 73: Xenobiotic Inhibition of Dopamine-beta-Hydroxylase and subsequent reduced fecundity 126: Alpha-noradrenergic antagonism leads to reduced fecundity via delayed ovulation
528	Decreased, Synthesis of NE Short Name Decreased, Synthesis of NE	1	Cellular	Nov 29, 2016	Sep 16, 2017	73: Xenobiotic Inhibition of Dopamine-beta-Hydroxylase and subsequent reduced fecundity
529	Decreased, GnRH cfos activity Short Name Decreased, GnRH cfos activity	1	Molecular	Nov 29, 2016	Sep 16, 2017	2 AOPs 73: Xenobiotic Inhibition of Dopamine-beta-Hydroxylase and subsequent reduced fecundity 126: Alpha-noradrenergic antagonism leads to reduced fecundity via delayed ovulation
530	Decreased, GnRH pulsatility/release Short Name Decreased, GnRH pulsatility/release	1	Cellular	Nov 29, 2016	Sep 16, 2017	2 AOPs 73: Xenobiotic Inhibition of Dopamine-beta-Hydroxylase and subsequent reduced fecundity 126: Alpha-noradrenergic antagonism leads to reduced fecundity via delayed ovulation
531	Decreased, LH Surge Short Name Decreased, LH Surge	2	Cellular	Nov 29, 2016	Sep 16, 2017	3 AOPs 73: Xenobiotic Inhibition of Dopamine-beta-Hydroxylase and subsequent reduced fecundity 126: Alpha-noradrenergic antagonism leads to reduced fecundity via delayed ovulation 512: Reduced availability of GnRH leading to uterine adenocarcinoma via increased estrogen availability at target organ level
532	Delayed, Ovulation Short Name Delayed, Ovulation	1	Individual	Nov 29, 2016	Dec 3, 2016	2 AOPs 73: Xenobiotic Inhibition of Dopamine-beta-Hydroxylase and subsequent reduced fecundity 126: Alpha-noradrenergic antagonism leads to reduced fecundity via delayed ovulation
533	Decreased, Cortical granule release/distribution upon fertilization Short Name	1	Cellular	Nov 29, 2016	Sep 16, 2017	2 AOPs 73: Xenobiotic Inhibition of Dopamine-beta-Hydroxylase and subsequent reduced fecundity 126: Alpha-noradrenergic antagonism leads to reduced fecundity via delayed ovulation
534	Altered, Formation of cortical envelope Short Name Altered, Formation of cortical envelope	1	Cellular	Nov 29, 2016	Sep 16, 2017	2 AOPs 73: Xenobiotic Inhibition of Dopamine-beta-Hydroxylase and subsequent reduced fecundity 126: Alpha-noradrenergic antagonism leads to reduced fecundity via delayed ovulation
535	Abnormal, Sperm penetration (polyspermy) Short Name	1	Cellular	Nov 29, 2016	Sep 16, 2017	2 AOPs 73: Xenobiotic Inhibition of Dopamine-beta-Hydroxylase and subsequent reduced fecundity 126: Alpha-noradrenergic antagonism leads to reduced fecundity via delayed ovulation
536	Altered, Chromosome number (polyploid) zygote Short Name	1	Cellular	Nov 29, 2016	Sep 16, 2017	2 AOPs 73: Xenobiotic Inhibition of Dopamine-beta-Hydroxylase and subsequent reduced fecundity 126: Alpha-noradrenergic antagonism leads to reduced fecundity via delayed ovulation
540	Decreased testosterone by the fetal Leydig cells, Dysgensis of fetal Leydig cells Short Name	2	Organ	Nov 29, 2016	Dec 3, 2016	74: Modulation of Adult Leydig Cell Function Subsequent to Hypermethylation in the Fetal Testis
541	Decreased testosterone by the fetal Leydig cells, Decreased COUP-TFII stem Leydig cells Short Name	2	Cellular	Nov 29, 2016	Dec 3, 2016	74: Modulation of Adult Leydig Cell Function Subsequent to Hypermethylation in the Fetal Testis
543	Decreased fertility in the adult, Decreased sperm quantity and/or quality in the adult testis Short Name	2	Individual	Nov 29, 2016	Dec 3, 2016	74: Modulation of Adult Leydig Cell Function Subsequent to Hypermethylation in the Fetal Testis
559	Activation, Nicotinic acetylcholine receptor Short Name	1	Molecular	Nov 29, 2016	Jun 7, 2018	9 AOPs 77: Nicotinic acetylcholine receptor activation contributes to abnormal foraging and leads to colony death/failure 1 78: Nicotinic acetylcholine receptor activation contributes to abnormal role change within the worker bee caste leading to colony death failure 1 79: Nicotinic acetylcholine receptor activation contributes to impaired hive thermoregulation and leads to colony loss/failure 87: Nicotinic acetylcholine receptor activation contributes to abnormal foraging and leads to colony loss/failure 88: Nicotinic acetylcholine receptor activation contributes to abnormal foraging and leads to colony loss/failure via abnormal role change within caste 89: Nicotinic acetylcholine receptor activation followed by desensitization contributes to abnormal foraging and directly leads to colony loss/failure 90: Nicotinic acetylcholine receptor activation contributes to abnormal roll change within the worker bee caste leading to colony loss/failure 2 80: Nicotinic acetylcholine receptor activation contributes to accumulation of damaged mitochondrial DNA and leads to colony loss/failure 178: Nicotinic acetylcholine receptor activation contributes to mitochondrial dysfunction and leads to colony loss/failure
560	Abnormal, Foraging activity and behavior Short Name	1	Individual	Nov 29, 2016	Jun 7, 2018	9 AOPs 77: Nicotinic acetylcholine receptor activation contributes to abnormal foraging and leads to colony death/failure 1 81: Increased metabolic stress contributes to abnormal foraging and leads to colony loss/failure 85: Suppression of immune system contributes to abnormal foraging and leads to colony loss/failure 87: Nicotinic acetylcholine receptor activation contributes to abnormal foraging and leads to colony loss/failure 88: Nicotinic acetylcholine receptor activation contributes to abnormal foraging and leads to colony loss/failure via abnormal role change within caste 89: Nicotinic acetylcholine receptor activation followed by desensitization contributes to abnormal foraging and directly leads to colony loss/failure 180: Varroa mite infestation contributes to abnormal foraging leading to colony loss/failure 182: Weather event contributes abnormal foraging leading to colony loss/failure 183: Nosema infection increases energetic demands leading to colony loss/failure
561	Reduced, Food storage Short Name Reduced, Food storage	1	Population	Nov 29, 2016	Dec 3, 2016	86: Decrease Glucose oxidase activity contributes to reduction of antiseptic in food and leads to colony loss/failure
563	Death/Failure, Colony Short Name Death/Failure, Colony	1	Population	Nov 29, 2016	Jun 7, 2018	21 AOPs 78: Nicotinic acetylcholine receptor activation contributes to abnormal role change within the worker bee caste leading to colony death failure 1 79: Nicotinic acetylcholine receptor activation contributes to impaired hive thermoregulation and leads to colony loss/failure 80: Nicotinic acetylcholine receptor activation contributes to accumulation of damaged mitochondrial DNA and leads to colony loss/failure 82: Abnormal role change in worker caste contributes to reduced brood care and leads to colony loss/failure 84: Suppression of immune system contributes to impaired development and leads to colony loss/failure 85: Suppression of immune system contributes to abnormal foraging and leads to colony loss/failure 86: Decrease Glucose oxidase activity contributes to reduction of antiseptic in food and leads to colony loss/failure 87: Nicotinic acetylcholine receptor activation contributes to abnormal foraging and leads to colony loss/failure 88: Nicotinic acetylcholine receptor activation contributes to abnormal foraging and leads to colony loss/failure via abnormal role change within caste 89: Nicotinic acetylcholine receptor activation followed by desensitization contributes to abnormal foraging and directly leads to colony loss/failure 90: Nicotinic acetylcholine receptor activation contributes to abnormal roll change within the worker bee caste leading to colony loss/failure 2 77: Nicotinic acetylcholine receptor activation contributes to abnormal foraging and leads to colony death/failure 1 81: Increased metabolic stress contributes to abnormal foraging and leads to colony loss/failure 178: Nicotinic acetylcholine receptor activation contributes to mitochondrial dysfunction and leads to colony loss/failure 179: Varroa mite infestation increases virus levels leading to colony loss/failure 180: Varroa mite infestation contributes to abnormal foraging leading to colony loss/failure 181: Weather event contributes to colony loss/failure 182: Weather event contributes abnormal foraging leading to colony loss/failure 183: Nosema infection increases energetic demands leading to colony loss/failure 184: Nosema infection causes abnormal role change that leads to colony loss/failure 185: Queen egg-laying decrease leads to colony loss/failure
564	Abnormal, Roll change within caste Short Name Abnormal, Roll change within caste	0	Population	Nov 29, 2016	Dec 3, 2016	4 AOPs 78: Nicotinic acetylcholine receptor activation contributes to abnormal role change within the worker bee caste leading to colony death failure 1 82: Abnormal role change in worker caste contributes to reduced brood care and leads to colony loss/failure 86: Decrease Glucose oxidase activity contributes to reduction of antiseptic in food and leads to colony loss/failure 90: Nicotinic acetylcholine receptor activation contributes to abnormal roll change within the worker bee caste leading to colony loss/failure 2
565	Reduced, Brood care Short Name Reduced, Brood care	2	Population	Nov 29, 2016	Dec 3, 2016	3 AOPs 78: Nicotinic acetylcholine receptor activation contributes to abnormal role change within the worker bee caste leading to colony death failure 1 82: Abnormal role change in worker caste contributes to reduced brood care and leads to colony loss/failure 90: Nicotinic acetylcholine receptor activation contributes to abnormal roll change within the worker bee caste leading to colony loss/failure 2