AOP-Wiki

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All Key Events

Showing 626 to 650 of 1781 Key Events

ID	Title	Event Component Count	Biological Organization	Created At	Last Updated	AOPs

1051	Hyperplasia, ovarian stromal cells Short Name Hyperplasia, ovarian stromal cells	1	Cellular	Nov 29, 2016	Sep 16, 2017	165: Antiestrogen activity leading to ovarian adenomas and granular cell tumors in the mouse
1052	Hyperplasia, ovarian epithelium Short Name Hyperplasia, ovarian epithelium	1	Tissue	Nov 29, 2016	Sep 16, 2017	2 AOPs 165: Antiestrogen activity leading to ovarian adenomas and granular cell tumors in the mouse 440: Hypothalamus estrogen receptors activity suppression leading to ovarian cancer via ovarian epithelial cell hyperplasia
1053	Promotion, ovarian adenomas Short Name Promotion, ovarian adenomas	1	Tissue	Nov 29, 2016	Dec 3, 2016	2 AOPs 165: Antiestrogen activity leading to ovarian adenomas and granular cell tumors in the mouse 440: Hypothalamus estrogen receptors activity suppression leading to ovarian cancer via ovarian epithelial cell hyperplasia
1054	Promotion, ovarian granular cell tumors Short Name Promotion, ovarian granular cell tumors	1	Cellular	Nov 29, 2016	Dec 3, 2016	165: Antiestrogen activity leading to ovarian adenomas and granular cell tumors in the mouse
1055	Decreased, Reduced estradiol in circulation decreases estrogen concentration at hypothalamus Short Name	0		Nov 29, 2016	Nov 29, 2016	None
1056	Decrease, E2 blood concentrations at hypothalamus Short Name	1	Tissue	Nov 29, 2016	Sep 16, 2017	165: Antiestrogen activity leading to ovarian adenomas and granular cell tumors in the mouse
1057	Increased, PPAR-alpha activation Short Name Increased, PPAR-alpha activation	1	Molecular	Nov 29, 2016	Sep 16, 2017	166: PPARalpha activation leading to pancreatic acinar tumors in the rat and mouse
1058	Decreased, bile flow Short Name Decreased, bile flow	1	Organ	Nov 29, 2016	Sep 16, 2017	166: PPARalpha activation leading to pancreatic acinar tumors in the rat and mouse
1059	Increased, cholestasis Short Name Increased, cholestasis	1	Organ	Nov 29, 2016	Sep 16, 2017	166: PPARalpha activation leading to pancreatic acinar tumors in the rat and mouse
1060	Alteration, lipid metabolism Short Name Alteration, lipid metabolism	1	Cellular	Nov 29, 2016	Oct 30, 2023	2 AOPs 166: PPARalpha activation leading to pancreatic acinar tumors in the rat and mouse 513: Reactive Oxygen (ROS) formation leads to cancer via Peroxisome proliferation-activated receptor (PPAR) pathway
1061	prolonged, elevation of serun CCK Short Name prolonged, elevation of serun CCK	1	Tissue	Nov 29, 2016	Sep 16, 2017	166: PPARalpha activation leading to pancreatic acinar tumors in the rat and mouse
1062	Increased, Cellular proliferation / hyperplasia of acinar cells Short Name	1	Cellular	Nov 29, 2016	Sep 16, 2017	166: PPARalpha activation leading to pancreatic acinar tumors in the rat and mouse
1063	Increased, Pancreatic acinar tumors Short Name Increased, Pancreatic acinar tumors	1	Organ	Nov 29, 2016	Sep 16, 2017	166: PPARalpha activation leading to pancreatic acinar tumors in the rat and mouse
1064	prepubertal increase, Estrogen receptor (ER) activity Short Name	1	Molecular	Nov 29, 2016	Dec 3, 2016	167: Early-life estrogen receptor activity leading to endometrial carcinoma in the mouse.
1065	Activation, estrogen receptor alpha Short Name Activation, estrogen receptor alpha	1	Molecular	Nov 29, 2016	Dec 3, 2016	3 AOPs 167: Early-life estrogen receptor activity leading to endometrial carcinoma in the mouse. 445: Estrogen Receptor Alpha Agonism leads to Impaired Reproduction 503: Activation of uterine estrogen receptor-alfa leading to endometrial adenocarcinoma, via epigenetic modulation
1066	Promotion, SIX-1 postive basal-type progenitor cells Short Name	1	Cellular	Nov 29, 2016	Sep 16, 2017	167: Early-life estrogen receptor activity leading to endometrial carcinoma in the mouse.
1067	Proliferation/Clonal Expansion, aberrant basal cells Short Name	1	Cellular	Nov 29, 2016	Sep 16, 2017	167: Early-life estrogen receptor activity leading to endometrial carcinoma in the mouse.
1068	squamous metaplasia, aberrant basal cells Short Name	1	Tissue	Nov 29, 2016	Dec 3, 2016	167: Early-life estrogen receptor activity leading to endometrial carcinoma in the mouse.
1069	Increased, Hyperplasia (glandular epithelial cells of endometrium) Short Name	1	Cellular	Nov 29, 2016	Sep 16, 2017	167: Early-life estrogen receptor activity leading to endometrial carcinoma in the mouse.
1070	Increased, adenosquamous carcinomas of endometrium Short Name	1	Tissue	Nov 29, 2016	Sep 16, 2017	167: Early-life estrogen receptor activity leading to endometrial carcinoma in the mouse.
1071	Decreased, GnRH pulsatility/release in hypothalamus Short Name	1	Cellular	Nov 29, 2016	Sep 16, 2017	2 AOPs 168: GnRH pulse disruption leading to mammary adenomas and carcinomas in the SD rat. 169: GnRH pulse disruption leading to pituitary adenomas and carcinomas in the SD rat.
1072	Decreased, LH Surge from anterior pituitary Short Name	1	Cellular	Nov 29, 2016	Dec 3, 2016	2 AOPs 168: GnRH pulse disruption leading to mammary adenomas and carcinomas in the SD rat. 169: GnRH pulse disruption leading to pituitary adenomas and carcinomas in the SD rat.
1073	anovulation, Short Name anovulation,	0		Nov 29, 2016	Nov 29, 2016	None
1074	interruption, Ovulation Short Name interruption, Ovulation	1	Individual	Nov 29, 2016	Dec 3, 2016	2 AOPs 168: GnRH pulse disruption leading to mammary adenomas and carcinomas in the SD rat. 169: GnRH pulse disruption leading to pituitary adenomas and carcinomas in the SD rat.
1075	prolonged, estrus Short Name prolonged, estrus	1	Individual	Nov 29, 2016	Dec 3, 2016	2 AOPs 168: GnRH pulse disruption leading to mammary adenomas and carcinomas in the SD rat. 169: GnRH pulse disruption leading to pituitary adenomas and carcinomas in the SD rat.