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All Key Events

Showing 651 to 675 of 1781 Key Events

ID	Title	Event Component Count	Biological Organization	Created At	Last Updated	AOPs

1076	Increased, circulating estrogen levels Short Name Increased, circulating estrogen levels	1	Organ	Nov 29, 2016	Dec 3, 2016	3 AOPs 168: GnRH pulse disruption leading to mammary adenomas and carcinomas in the SD rat. 169: GnRH pulse disruption leading to pituitary adenomas and carcinomas in the SD rat. 440: Hypothalamus estrogen receptors activity suppression leading to ovarian cancer via ovarian epithelial cell hyperplasia
1077	Increased, prolactin exposure Short Name Increased, prolactin exposure	1	Tissue	Nov 29, 2016	Dec 3, 2016	168: GnRH pulse disruption leading to mammary adenomas and carcinomas in the SD rat.
1078	Hyperplasia, Mammary gland Short Name Hyperplasia, Mammary gland	1	Tissue	Nov 29, 2016	Sep 16, 2017	168: GnRH pulse disruption leading to mammary adenomas and carcinomas in the SD rat.
1079	Increased, Adenomas/carcinomas (mammary) Short Name	2	Tissue	Nov 29, 2016	Sep 16, 2017	2 AOPs 168: GnRH pulse disruption leading to mammary adenomas and carcinomas in the SD rat. 170: Anti-dopaminergic activity leading to mammary adenomas and carcinomas in the SD rat
1080	Increased, latency period Short Name Increased, latency period	1	Individual	Nov 29, 2016	Dec 3, 2016	2 AOPs 168: GnRH pulse disruption leading to mammary adenomas and carcinomas in the SD rat. 170: Anti-dopaminergic activity leading to mammary adenomas and carcinomas in the SD rat
1081	Increased, lactotroph hyperplasia and hypertrophy Short Name	2	Cellular	Nov 29, 2016	Sep 16, 2017	169: GnRH pulse disruption leading to pituitary adenomas and carcinomas in the SD rat.
1082	Increased, adenomas (pituitary) Short Name Increased, adenomas (pituitary)	1	Tissue	Nov 29, 2016	Sep 16, 2017	169: GnRH pulse disruption leading to pituitary adenomas and carcinomas in the SD rat.
1083	Decreased, Dopaminergic activity Short Name Decreased, Dopaminergic activity	1	Cellular	Nov 29, 2016	Dec 3, 2016	170: Anti-dopaminergic activity leading to mammary adenomas and carcinomas in the SD rat
1084	Increased, prolactin secretion Short Name Increased, prolactin secretion	1	Tissue	Nov 29, 2016	Dec 3, 2016	170: Anti-dopaminergic activity leading to mammary adenomas and carcinomas in the SD rat
1085	Increased, hyperplasia (mammary gland) Short Name Increased, hyperplasia (mammary gland)	1	Tissue	Nov 29, 2016	Sep 16, 2017	170: Anti-dopaminergic activity leading to mammary adenomas and carcinomas in the SD rat
1086	persistent, cytotoxicity (pleura or peritoneum) Short Name	1	Cellular	Nov 29, 2016	Sep 16, 2017	171: Chronic cytotoxicity of the serous membrane leading to pleural/peritoneal mesotheliomas in the rat.
1087	Increased, inflammation Short Name Increased, inflammation	1	Cellular	Nov 29, 2016	Dec 3, 2016	171: Chronic cytotoxicity of the serous membrane leading to pleural/peritoneal mesotheliomas in the rat.
1088	Increased, Oxidative Stress Short Name Increased, Oxidative Stress	1	Molecular	Nov 29, 2016	Feb 3, 2022	12 AOPs 171: Chronic cytotoxicity of the serous membrane leading to pleural/peritoneal mesotheliomas in the rat. 138: Organic anion transporter (OAT1) inhibition leading to renal failure and mortality 177: Cyclooxygenase 1 (COX1) inhibition leading to renal failure and mortality 186: unknown MIE leading to renal failure and mortality 200: Estrogen receptor activation leading to breast cancer 396: Deposition of ionizing energy leads to population decline via impaired meiosis 377: Dysregulated prolonged Toll Like Receptor 9 (TLR9) activation leading to Multi Organ Failure involving Acute Respiratory Distress Syndrome (ARDS) 444: Ionizing radiation leads to reduced reproduction in Eisenia fetida via reduced spermatogenesis and cocoon hatchability 447: Kidney failure induced by inhibition of mitochondrial electron transfer chain through apoptosis, inflammation and oxidative stress pathways 476: Adverse Outcome Pathways diagram related to PBDEs associated male reproductive toxicity 488: Increased reactive oxygen species production leading to decreased cognitive function 497: ERa inactivation alters mitochondrial functions and insulin signalling in skeletal muscle and leads to insulin resistance and metabolic syndrome
1089	Increased, Cell Proliferation (mesothelium) Short Name	1	Cellular	Nov 29, 2016	Sep 16, 2017	171: Chronic cytotoxicity of the serous membrane leading to pleural/peritoneal mesotheliomas in the rat.
1090	Increased, mesotheliomas Short Name Increased, mesotheliomas	1	Tissue	Nov 29, 2016	Dec 3, 2016	2 AOPs 171: Chronic cytotoxicity of the serous membrane leading to pleural/peritoneal mesotheliomas in the rat. 409: Frustrated phagocytosis leads to malignant mesothelioma
1091	Physical and/or chemical interaction with cellular components, Short Name	0		Nov 29, 2016	Nov 29, 2016	None
1092	Pulmonary Fibrosis, Short Name Pulmonary Fibrosis,	0		Nov 29, 2016	Nov 29, 2016	None
1093	Decreased, Thyroxine (T4) in tissues Short Name Decreased, Thyroxine (T4) in tissues	2	Tissue	Nov 29, 2016	Sep 3, 2020	None
1094	, hyperuricemia Short Name , hyperuricemia	0		Nov 29, 2016	Nov 29, 2016	None
1095	hyperuricemia, Short Name hyperuricemia,	0		Nov 29, 2016	Nov 29, 2016	None
1096	Increased, blood uric acid concentration Short Name	1	Tissue	Nov 29, 2016	Sep 16, 2017	2 AOPs 138: Organic anion transporter (OAT1) inhibition leading to renal failure and mortality 177: Cyclooxygenase 1 (COX1) inhibition leading to renal failure and mortality
1097	Occurrence, renal proximal tubular necrosis Short Name	1	Tissue	Nov 29, 2016	Sep 16, 2017	4 AOPs 138: Organic anion transporter (OAT1) inhibition leading to renal failure and mortality 177: Cyclooxygenase 1 (COX1) inhibition leading to renal failure and mortality 186: unknown MIE leading to renal failure and mortality 447: Kidney failure induced by inhibition of mitochondrial electron transfer chain through apoptosis, inflammation and oxidative stress pathways
1098	Increased, blood potassium concentration Short Name	1	Tissue	Nov 29, 2016	Sep 16, 2017	3 AOPs 138: Organic anion transporter (OAT1) inhibition leading to renal failure and mortality 177: Cyclooxygenase 1 (COX1) inhibition leading to renal failure and mortality 186: unknown MIE leading to renal failure and mortality
1100	Occurrence, cardiac arrthymia Short Name Occurrence, cardiac arrthymia	0		Nov 29, 2016	Nov 29, 2016	None
1101	Altered, Amphibian metamorphosis Short Name Altered, Amphibian metamorphosis	2	Organ	Nov 29, 2016	Sep 2, 2020	11 AOPs 175: Thyroperoxidase inhibition leading to altered amphibian metamorphosis 176: Sodium Iodide Symporter (NIS) Inhibition leading to altered amphibian metamorphosis 188: Iodotyrosine deiodinase (IYD) inhibition leading to altered amphibian metamorphosis 189: Type I iodothyronine deiodinase (DIO1) inhibition leading to altered amphibian metamorphosis 190: Type II iodothyronine deiodinase (DIO2) inhibition leading to altered amphibian metamorphosis 191: Type III iodotyrosine deiodinase (DIO3) inhibition leading to altered amphibian metamorphosis 192: Pendrin inhibition leading to altered amphibian metamorphosis 193: Dual oxidase (DUOX) inhibition leading to altered amphibian metamorphosis 194: Hepatic nuclear receptor activation leading to altered amphibian metamorphosis 366: Competitive binding to thyroid hormone carrier protein transthyretin (TTR) leading to altered amphibian metamorphosis 367: Competitive binding to thyroid hormone carrier protein thyroid binding globulin (TBG) leading to altered amphibian metamorphosis