AOP-Wiki

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All Key Events

Showing 1451 to 1475 of 1781 Key Events

ID	Title	Event Component Count	Biological Organization	Created At	Last Updated	AOPs

1914	Platelet activation, Increased Short Name Platelet activation, Increased	0	Cellular	Aug 4, 2021	Aug 4, 2021	412: Endothelial cell dysfunction leading to thromboinflammation
1915	Neutrophil activation, Increased Short Name Neutrophil activation, Increased	0	Cellular	Aug 4, 2021	Aug 4, 2021	412: Endothelial cell dysfunction leading to thromboinflammation
1916	Thromboinflammation, Increased Short Name Thromboinflammation, Increased	0	Organ	Aug 4, 2021	Aug 4, 2021	412: Endothelial cell dysfunction leading to thromboinflammation
1917	Altered gene expression, NRF2 dependent antioxidant pathway Short Name	0	Molecular	Aug 17, 2021	Aug 19, 2021	3 AOPs 421: PPARG activation leading to intrahepatic cholestasis 420: Aryl hydrocarbon receptor activation leading to lung cancer through sustained NRF2 toxicity pathway 447: Kidney failure induced by inhibition of mitochondrial electron transfer chain through apoptosis, inflammation and oxidative stress pathways
1918	Increased，Myocardial apoptosis Short Name Increased，Myocardial apoptosis	0	Cellular	Aug 18, 2021	Sep 1, 2021	None
1919	Increased，Cardiac Dysregulation Short Name Increased，Cardiac dysfunction	0	Tissue	Aug 18, 2021	Sep 1, 2021	None
1920	Altered gene expression, TGF-β dependent fibrosis pathway Short Name	0	Molecular	Aug 19, 2021	Aug 19, 2021	414: Aryl hydrocarbon receptor activation leading to lung fibrosis through TGF-β dependent fibrosis toxicity pathway
1921	Altered gene expression, NF-kB dependent Interleukin-6 pathway Short Name	0	Molecular	Aug 19, 2021	Aug 19, 2021	2 AOPs 415: Aryl hydrocarbon receptor activation leading to lung fibrosis through IL-6 toxicity pathway 416: Aryl hydrocarbon receptor activation leading to lung cancer through IL-6 toxicity pathway
1922	Increased, Reactive metabolites production Short Name Increased, metabolites	0	Cellular	Aug 19, 2021	Aug 26, 2021	417: Aryl hydrocarbon receptor activation leading to lung cancer through AHR-ARNT toxicity pathway
1923	Altered gene expression, P53 dependent apoptosis pathway Short Name	0	Molecular	Aug 19, 2021	Aug 19, 2021	419: Aryl hydrocarbon receptor activation leading to impaired lung function through P53 toxicity pathway
1924	Increased，Cardiac fibrosis Short Name Increased，Cardiac fibrosis	0	Organ	Aug 19, 2021	Sep 1, 2021	None
1925	Increased，Vascular smooth muscle cell activation Short Name	0	Cellular	Aug 19, 2021	Sep 1, 2021	None
1926	Increased，Vascular fibrosis Short Name Increased，Vascular fibrosis	0	Tissue	Aug 19, 2021	Sep 1, 2021	None
1927	Increased，Vascular endothelial cell autophagy dysfunction Short Name	0	Cellular	Aug 19, 2021	Sep 1, 2021	None
1928	increased, Vascular endothelial dysfunction Short Name	0	Tissue	Aug 19, 2021	Jun 19, 2024	5 AOPs 507: Nrf2 inhibition leading to vascular disrupting effects via inflammation pathway 508: Nrf2 inhibition leading to vascular disrupting effects through activating HIF1α, Semaphorin 6A, and Dll4-Notch pathway 509: Nrf2 inhibition leading to vascular disrupting effects through activating apoptosis signal pathway and mitochondrial dysfunction 510: Demethylation of PPAR promotor leading to vascular disrupting effects 511: The AOP framework on ROS-mediated oxidative stress induced vascular disrupting effects
1929	Increased incidence of cardiovascular morbidity and mortality in the general population Short Name	0	Population	Aug 21, 2021	Aug 21, 2021	None
1930	altered, inner ear development Short Name Altered, inner ear development	1	Organ	Aug 23, 2021	Aug 24, 2021	410: GSK3beta inactivation leading to increased mortality via defects in developing inner ear
1931	Intestinal barrier, disruption Short Name Disruption of the intestinal barrier	1	Organ	Sep 1, 2021	Jun 21, 2022	2 AOPs 422: Binding of SARS-CoV-2 to ACE2 in enterocytes leads to intestinal barrier disruption 530: Endocytotic lysosomal uptake leads to intestinal barrier disruption
1932	Gastrointestinal disorders Short Name GI disorders	0	Individual	Sep 2, 2021	Sep 8, 2021	None
1933	Increased, Interleukin-6 production Short Name Increased IL-6 production	0	Cellular	Sep 20, 2021	Sep 20, 2021	416: Aryl hydrocarbon receptor activation leading to lung cancer through IL-6 toxicity pathway
1934	Myocardial Infarction Short Name Heart attack	0	Organ	Oct 15, 2021	Oct 15, 2021	426: SARS-CoV-2 spike protein binding to ACE2 receptors expressed on pericytes leads to endothelial cell dysfunction, microvascular injury and myocardial infarction.
1935	Angiotensin (1-7) levels diminished Short Name Ang (1-7) levels reduced	0	Molecular	Oct 15, 2021	Oct 15, 2021	427: ACE2 downregulation following SARS-CoV-2 infection triggers dysregulation of RAAS and can lead to heart failure.
1936	Angiotensin II degradation reduced Short Name Degradation of Ang-II reduced	0	Molecular	Oct 17, 2021	Oct 17, 2021	427: ACE2 downregulation following SARS-CoV-2 infection triggers dysregulation of RAAS and can lead to heart failure.
1937	ADAM17 expression induction Short Name ADAM17 induction	0	Cellular	Oct 17, 2021	Oct 17, 2021	427: ACE2 downregulation following SARS-CoV-2 infection triggers dysregulation of RAAS and can lead to heart failure.
1938	ACE2 increased shedding Short Name ACE2 increased shedding	0	Molecular	Oct 17, 2021	Oct 17, 2021	427: ACE2 downregulation following SARS-CoV-2 infection triggers dysregulation of RAAS and can lead to heart failure.