AOP-Wiki

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All Key Events

Showing 426 to 450 of 1781 Key Events

ID	Title	Event Component Count	Biological Organization	Created At	Last Updated	AOPs

778	Increase, Regenerative cell proliferation (corneal cells) Short Name	1	Cellular	Nov 29, 2016	Sep 16, 2017	114: HPPD inhibition leading to corneal papillomas and carcinomas (in rat)
779	Increase, Papillomas/carcinomas (squamous cells) Short Name	2	Cellular	Nov 29, 2016	Sep 16, 2017	2 AOPs 114: HPPD inhibition leading to corneal papillomas and carcinomas (in rat) 115: Epithelial cytotoxicity leading to forestomach tumors (in mouse and rat)
780	Increase, Cytotoxicity (epithelial cells) Short Name	1	Cellular	Nov 29, 2016	Sep 16, 2017	2 AOPs 115: Epithelial cytotoxicity leading to forestomach tumors (in mouse and rat) 451: Interaction with lung resident cell membrane components leads to lung cancer
781	Increase, Regenerative cell proliferation (forestomach epithelial cells) Short Name	1	Cellular	Nov 29, 2016	Sep 16, 2017	115: Epithelial cytotoxicity leading to forestomach tumors (in mouse and rat)
782	Increase, Hyperplasia (forestomach epithelial cells) Short Name	1	Cellular	Nov 29, 2016	Sep 16, 2017	115: Epithelial cytotoxicity leading to forestomach tumors (in mouse and rat)
783	Increase, Cytotoxicity (tubular epithelial cells) Short Name	1	Cellular	Nov 29, 2016	Sep 16, 2017	116: Cytotoxicity leading to renal tubular adenomas and carcinomas (in male rat)
784	Increase, Hyperplasia (tubular epithelial cells) Short Name	1	Cellular	Nov 29, 2016	Sep 16, 2017	116: Cytotoxicity leading to renal tubular adenomas and carcinomas (in male rat)
785	Activation, Androgen receptor Short Name Activation, Androgen receptor	1	Molecular	Nov 29, 2016	Dec 3, 2016	2 AOPs 117: Androgen receptor activation leading to hepatocellular adenomas and carcinomas (in mouse and rat) 495: Androgen receptor activation leading to prostate cancer
786	Increase, Cytotoxicity (hepatocytes) Short Name Increase, Cytotoxicity (hepatocytes)	1	Cellular	Nov 29, 2016	Sep 16, 2017	118: Chronic cytotoxicity leading to hepatocellular adenomas and carcinomas (in mouse and rat)
787	Increase, Regenerative cell proliferation (hepatocytes) Short Name	1	Cellular	Nov 29, 2016	Sep 16, 2017	118: Chronic cytotoxicity leading to hepatocellular adenomas and carcinomas (in mouse and rat)
788	Decrease, Incorporation of active iodide into iodotyrosines Short Name	1	Cellular	Nov 29, 2016	Sep 16, 2017	None
790	Inhibition, 5α-reductase activity Short Name Inhibition, 5α-reductase activity	1	Cellular	Nov 29, 2016	Dec 3, 2016	120: Inhibition of 5α-reductase leading to Leydig cell tumors (in rat)
791	Increased, Leutinizing hormone (LH) Short Name Increased, Leutinizing hormone (LH)	1	Tissue	Nov 29, 2016	Sep 16, 2017	120: Inhibition of 5α-reductase leading to Leydig cell tumors (in rat)
792	Decrease, Bioactivation of testosterone Short Name Decrease, Bioactivation of testosterone	1	Tissue	Nov 29, 2016	Sep 16, 2017	None
793	Increase, Urinary bladder calculi Short Name Increase, Urinary bladder calculi	1	Organ	Nov 29, 2016	Oct 26, 2017	121: Urinary bladder calculi leading to urothelial papillomas and carcinomas (in mouse and rat)
794	Increase, Cytotoxicity (urothelial cells) Short Name	1	Cellular	Nov 29, 2016	Sep 16, 2017	121: Urinary bladder calculi leading to urothelial papillomas and carcinomas (in mouse and rat)
795	Increase, Regenerative cell proliferation (urothelial cells) Short Name	1	Cellular	Nov 29, 2016	Sep 16, 2017	2 AOPs 121: Urinary bladder calculi leading to urothelial papillomas and carcinomas (in mouse and rat) 335: AOP for urothelial carcinogenesis due to chemical cytotoxicity by mitochondrial impairment
796	Increase, Hyperplasia (urothelial) Short Name Increase, Hyperplasia (urothelial)	1	Cellular	Nov 29, 2016	Sep 16, 2017	2 AOPs 121: Urinary bladder calculi leading to urothelial papillomas and carcinomas (in mouse and rat) 335: AOP for urothelial carcinogenesis due to chemical cytotoxicity by mitochondrial impairment
797	Increase, Adenomas/carcinomas (urothelial) Short Name	2	Tissue	Nov 29, 2016	Sep 16, 2017	121: Urinary bladder calculi leading to urothelial papillomas and carcinomas (in mouse and rat)
798	Inhibition, Prolyl hydroxylases Short Name Inhibition, Prolyl hydroxylases	1	Cellular	Nov 29, 2016	Dec 3, 2016	122: Prolyl hydroxylase inhibition leading to reproductive dysfunction via increased HIF1 heterodimer formation
799	Increased, HIF-1 heterodimer Short Name Increased, HIF-1 heterodimer	2	Cellular	Nov 29, 2016	Dec 3, 2016	2 AOPs 122: Prolyl hydroxylase inhibition leading to reproductive dysfunction via increased HIF1 heterodimer formation 123: Unknown MIE leading to reproductive dysfunction via increased HIF-1alpha transcription
800	Decreased, Aromatase (Cyp19a1) mRNA Short Name Decreased, Aromatase (Cyp19a1) mRNA	2	Cellular	Nov 29, 2016	Sep 16, 2017	2 AOPs 122: Prolyl hydroxylase inhibition leading to reproductive dysfunction via increased HIF1 heterodimer formation 123: Unknown MIE leading to reproductive dysfunction via increased HIF-1alpha transcription
801	modulation, Unknown Short Name modulation, Unknown	1	Molecular	Nov 29, 2016	Dec 3, 2016	123: Unknown MIE leading to reproductive dysfunction via increased HIF-1alpha transcription
802	Increased, HIF-1 alpha transcription Short Name Increased, HIF-1 alpha transcription	1	Cellular	Nov 29, 2016	Dec 3, 2016	123: Unknown MIE leading to reproductive dysfunction via increased HIF-1alpha transcription
804	Inhibition, HMG-CoA reductase Short Name Inhibition, HMG-CoA reductase	1	Cellular	Nov 29, 2016	Dec 3, 2016	124: HMG-CoA reductase inhibition leading to decreased fertility