AOP-Wiki

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All Key Events

Showing 601 to 625 of 1781 Key Events

ID	Title	Event Component Count	Biological Organization	Created At	Last Updated	AOPs

1026	Increased Apoptosis, Adenomas/carcinomas (follicular cell) Short Name	2	Tissue	Nov 29, 2016	Sep 16, 2017	None
1027	, Learning and memory, impairment Short Name , Learning and memory, impairment	0		Nov 29, 2016	Nov 29, 2016	None
1028	Activation of specific nuclear receptors, PPAR-gamma activation Short Name	1	Molecular	Nov 29, 2016	Sep 16, 2017	2 AOPs 163: PPARgamma activation leading to sarcomas in rats, mice, and hamsters 72: Epigenetic modification of PPARG leading to adipogenesis
1029	Increased, adipogenesis Short Name Increased, adipogenesis	1	Cellular	Nov 29, 2016	Sep 16, 2017	163: PPARgamma activation leading to sarcomas in rats, mice, and hamsters
1030	Increased, Short Name Increased,	0		Nov 29, 2016	Nov 29, 2016	None
1031	Increased, release of growth factors Short Name Increased, release of growth factors	0		Nov 29, 2016	Nov 29, 2016	None
1032	Increased, secretion of local growth factors Short Name	1	Cellular	Nov 29, 2016	Sep 16, 2017	2 AOPs 163: PPARgamma activation leading to sarcomas in rats, mice, and hamsters 171: Chronic cytotoxicity of the serous membrane leading to pleural/peritoneal mesotheliomas in the rat.
1033	Increased, proliferation of mesenchymal cells Short Name	1	Cellular	Nov 29, 2016	Sep 16, 2017	163: PPARgamma activation leading to sarcomas in rats, mice, and hamsters
1034	Increased, IGF-1 (mouse) Short Name Increased, IGF-1 (mouse)	1	Cellular	Nov 29, 2016	Sep 16, 2017	163: PPARgamma activation leading to sarcomas in rats, mice, and hamsters
1035	Increased, Firbrosarcoma Short Name Increased, Firbrosarcoma	1	Tissue	Nov 29, 2016	Sep 16, 2017	163: PPARgamma activation leading to sarcomas in rats, mice, and hamsters
1036	Increased, liposarcoma Short Name Increased, liposarcoma	1	Tissue	Nov 29, 2016	Sep 16, 2017	163: PPARgamma activation leading to sarcomas in rats, mice, and hamsters
1037	Increased, hemagiosarcoma Short Name Increased, hemagiosarcoma	1	Tissue	Nov 29, 2016	Sep 16, 2017	163: PPARgamma activation leading to sarcomas in rats, mice, and hamsters
1038	Activation, beta-2 adrenergic receptor Short Name Activation, beta-2 adrenergic receptor	1	Molecular	Nov 29, 2016	Sep 16, 2017	164: Beta-2 adrenergic agonist activity leading to mesovarian leiomyomas in the rat and mouse
1039	Increased activity, beta-2 adrenergic receptor Short Name	1	Molecular	Nov 29, 2016	Sep 16, 2017	164: Beta-2 adrenergic agonist activity leading to mesovarian leiomyomas in the rat and mouse
1040	relaxation, smooth muscle Short Name relaxation, smooth muscle	1	Tissue	Nov 29, 2016	Dec 3, 2016	164: Beta-2 adrenergic agonist activity leading to mesovarian leiomyomas in the rat and mouse
1041	Proliferation, smooth muscle Short Name Proliferation, smooth muscle	0		Nov 29, 2016	Nov 29, 2016	None
1042	Proliferation/Clonal Expansion, smooth muscle Short Name	1	Cellular	Nov 29, 2016	Sep 16, 2017	164: Beta-2 adrenergic agonist activity leading to mesovarian leiomyomas in the rat and mouse
1043	Hypertrophy/hyperplasia, smooth muscle Short Name Hypertrophy/hyperplasia, smooth muscle	1	Cellular	Nov 29, 2016	Dec 3, 2016	164: Beta-2 adrenergic agonist activity leading to mesovarian leiomyomas in the rat and mouse
1044	Promotion, mesovarian leiomyomas Short Name Promotion, mesovarian leiomyomas	1	Tissue	Nov 29, 2016	Sep 16, 2017	164: Beta-2 adrenergic agonist activity leading to mesovarian leiomyomas in the rat and mouse
1045	Decreased, Ovarian E2 Short Name Decreased, Ovarian E2	1	Tissue	Nov 29, 2016	Sep 16, 2017	165: Antiestrogen activity leading to ovarian adenomas and granular cell tumors in the mouse
1046	Suppression, Estrogen receptor (ER) activity Short Name	1	Molecular	Nov 29, 2016	Feb 28, 2022	2 AOPs 165: Antiestrogen activity leading to ovarian adenomas and granular cell tumors in the mouse 440: Hypothalamus estrogen receptors activity suppression leading to ovarian cancer via ovarian epithelial cell hyperplasia
1047	Increased, secretion of GnRH from hypothalamus Short Name	1	Cellular	Nov 29, 2016	Sep 16, 2017	2 AOPs 165: Antiestrogen activity leading to ovarian adenomas and granular cell tumors in the mouse 440: Hypothalamus estrogen receptors activity suppression leading to ovarian cancer via ovarian epithelial cell hyperplasia
1048	Increased, secretion of leutenizing hormone Short Name	0		Nov 29, 2016	Nov 29, 2016	None
1049	Increased, secrection of FSH from anterior pituitary Short Name	1	Cellular	Nov 29, 2016	Dec 3, 2016	165: Antiestrogen activity leading to ovarian adenomas and granular cell tumors in the mouse
1050	Increased, secretion of LH from anterior pituitary Short Name	1	Cellular	Nov 29, 2016	Dec 3, 2016	2 AOPs 165: Antiestrogen activity leading to ovarian adenomas and granular cell tumors in the mouse 440: Hypothalamus estrogen receptors activity suppression leading to ovarian cancer via ovarian epithelial cell hyperplasia