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All Key Events

Showing 851 to 875 of 1781 Key Events

ID	Title	Event Component Count	Biological Organization	Created At	Last Updated	AOPs

1282	Activation, JAK/STAT pathway Short Name Activation, JAK/STAT pathway	2	Cellular	Feb 15, 2017	Sep 16, 2017	208: Janus kinase (JAK)/Signal transducer and activator of transcription (STAT) and Transforming growth factor (TGF)-beta pathways activation leading to reproductive failure
1283	Activation, TGF-beta pathway Short Name Activation, TGF-beta pathway	1	Cellular	Feb 15, 2017	Sep 16, 2017	2 AOPs 208: Janus kinase (JAK)/Signal transducer and activator of transcription (STAT) and Transforming growth factor (TGF)-beta pathways activation leading to reproductive failure 347: Toll-like receptor 4 activation and peroxisome proliferator-activated receptor gamma inactivation leading to pulmonary fibrosis
1284	Up Regulation, SREBF2 Short Name Up Regulation, SREBF2	1	Cellular	Feb 15, 2017	Sep 16, 2017	2 AOPs 209: Perturbation of cholesterol and glutathione homeostasis leading to hepatotoxicity: Integrated multi-OMICS approach for building AOP 401: G protein-coupled estrogen receptor 1 (GPER) signal pathway in the lipid metabolism disrupting effects
1285	Up Regulation, Unsaturated fatty acid Short Name Up Regulation, Unsaturated fatty acid	1	Cellular	Feb 15, 2017	Sep 16, 2017	209: Perturbation of cholesterol and glutathione homeostasis leading to hepatotoxicity: Integrated multi-OMICS approach for building AOP
1286	Down Regulation, GSS and GSTs gene Short Name Down Regulation, GSS and GSTs gene	2	Cellular	Feb 15, 2017	Sep 16, 2017	209: Perturbation of cholesterol and glutathione homeostasis leading to hepatotoxicity: Integrated multi-OMICS approach for building AOP
1287	Glutathione synthesis Short Name Glutathione synthesis	1	Cellular	Feb 15, 2017	Sep 16, 2017	209: Perturbation of cholesterol and glutathione homeostasis leading to hepatotoxicity: Integrated multi-OMICS approach for building AOP
1288	Activation, 3-hydroxy-3-methylglutaryl-CoA reductase gene Short Name	1	Cellular	Feb 15, 2017	Sep 16, 2017	209: Perturbation of cholesterol and glutathione homeostasis leading to hepatotoxicity: Integrated multi-OMICS approach for building AOP
1289	Perturbation of cholesterol Short Name Perturbation of cholesterol	1	Cellular	Feb 15, 2017	Sep 16, 2017	209: Perturbation of cholesterol and glutathione homeostasis leading to hepatotoxicity: Integrated multi-OMICS approach for building AOP
1290	Glutathione homeostasis Short Name Glutathione homeostasis	1	Cellular	Feb 15, 2017	Sep 16, 2017	209: Perturbation of cholesterol and glutathione homeostasis leading to hepatotoxicity: Integrated multi-OMICS approach for building AOP
1291	Hepatotoxicity Short Name Hepatotoxicity	0	Cellular	Feb 15, 2017	Feb 15, 2017	209: Perturbation of cholesterol and glutathione homeostasis leading to hepatotoxicity: Integrated multi-OMICS approach for building AOP
1292	Activation, JNK Short Name Activation, JNK	1	Cellular	Feb 15, 2017	Sep 16, 2017	2 AOPs 210: Activation of c-Jun N-terminal kinase (JNK) and Forkhead box O (FOXO) and reduction of WNT pathways leading to reproductive failure: Integrated multi-OMICS approach for AOP building 347: Toll-like receptor 4 activation and peroxisome proliferator-activated receptor gamma inactivation leading to pulmonary fibrosis
1293	Activation, FOXO Short Name Activation, FOXO	1	Cellular	Feb 15, 2017	Sep 16, 2017	210: Activation of c-Jun N-terminal kinase (JNK) and Forkhead box O (FOXO) and reduction of WNT pathways leading to reproductive failure: Integrated multi-OMICS approach for AOP building
1294	Inhibition, Wnt pathway Short Name Inhibition, Wnt pathway	1	Cellular	Feb 15, 2017	Sep 16, 2017	210: Activation of c-Jun N-terminal kinase (JNK) and Forkhead box O (FOXO) and reduction of WNT pathways leading to reproductive failure: Integrated multi-OMICS approach for AOP building
1295	Defect of Embryogenesis Short Name Defect of Embryogenesis	1	Tissue	Feb 15, 2017	Sep 16, 2017	210: Activation of c-Jun N-terminal kinase (JNK) and Forkhead box O (FOXO) and reduction of WNT pathways leading to reproductive failure: Integrated multi-OMICS approach for AOP building
1296	Increase, insulin Short Name Increase, insulin	0	Molecular	Apr 12, 2017	Apr 12, 2017	None
1297	Activation, insulin receptor Short Name Activation, insulin receptor	0	Molecular	Apr 12, 2017	Apr 12, 2017	None
1298	Activation, mTORC2 Short Name Activation, mTORC2	0	Molecular	Apr 12, 2017	Apr 12, 2017	None
1299	Activation, AKT Short Name Activation, AKT	0	Molecular	Apr 12, 2017	Apr 12, 2017	401: G protein-coupled estrogen receptor 1 (GPER) signal pathway in the lipid metabolism disrupting effects
1300	Activation, mTORC1 Short Name Activation, mTORC1	0	Molecular	Apr 12, 2017	Apr 12, 2017	401: G protein-coupled estrogen receptor 1 (GPER) signal pathway in the lipid metabolism disrupting effects
1301	Activation, SREBP-1 Short Name Activation, SREBP-1	0	Molecular	Apr 12, 2017	Apr 12, 2017	None
1302	Activation, L-FABP Short Name Activation, L-FABP	0	Molecular	Apr 12, 2017	Apr 13, 2017	None
1303	Activation, HSD17B4 Short Name Activation, HSD17B4	0	Molecular	Apr 12, 2017	Apr 12, 2017	None
1304	Activation, FXR Short Name Activation, FXR	0	Molecular	Apr 12, 2017	Apr 12, 2017	None
1305	Increase, cytosolic fatty acid Short Name Increase, cytosolic fatty acid	0	Cellular	Apr 12, 2017	Nov 27, 2017	213: Inhibition of fatty acid beta oxidation leading to nonalcoholic steatohepatitis (NASH)
1306	Increased, lipogenesis Short Name Increased, lipogenesis	0	Molecular	Apr 12, 2017	Apr 12, 2017	None