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Increase, DNA Damage leads to Tissue resident cell activation
Key Event Relationship Overview
AOPs Referencing Relationship
|AOP Name||Adjacency||Weight of Evidence||Quantitative Understanding||Point of Contact||Author Status||OECD Status|
|Increased reactive oxygen and nitrogen species (RONS) leading to increased risk of breast cancer||adjacent||Moderate||Not Specified||Evgeniia Kazymova (send email)||Under development: Not open for comment. Do not cite||Under Development|
|Increased DNA damage leading to increased risk of breast cancer||adjacent||Moderate||Not Specified||Allie Always (send email)||Under development: Not open for comment. Do not cite||Under Development|
Life Stage Applicability
Key Event Relationship Description
Evidence Collection Strategy
Evidence Supporting this KER
High. Biological plausibility is high since DNA damage generates inflammatory signals (DAMPS).