API XML

Aop: 294

AOP Title

?


leptin

Short name:

?

good

Graphical Representation

?

Click to download graphical representation template

Authors

?


Point of Contact

?


Arthur Author   (email point of contact)

Contributors

?


  • Arthur Author

Status

?

Author status OECD status OECD project SAAOP status
Under development: Not open for comment. Do not cite


This AOP was last modified on June 10, 2019 04:04

?

Revision dates for related pages

Page Revision Date/Time
Thyroperoxidase, Inhibition September 16, 2017 10:15
Thyroid hormone synthesis, Decreased September 17, 2017 18:27
Thyroxine (T4) in serum, Decreased September 17, 2017 18:37
Thyroxine (T4) in neuronal tissue, Decreased September 17, 2017 17:11
Hippocampal gene expression, Altered September 17, 2017 17:14
Hippocampal anatomy, Altered September 16, 2017 10:14
Hippocampal Physiology, Altered September 17, 2017 17:17
Altered, Amphibian metamorphosis December 03, 2016 16:37

Abstract

?



Background (optional)

?



Summary of the AOP

?


Events: Molecular Initiating Events (MIE)

?

Key Events (KE)

?

Adverse Outcomes (AO)

?

Sequence Type Event ID Title Short name
MIE 279 Thyroperoxidase, Inhibition Thyroperoxidase, Inhibition
KE 277 Thyroid hormone synthesis, Decreased TH synthesis, Decreased
KE 281 Thyroxine (T4) in serum, Decreased T4 in serum, Decreased
KE 280 Thyroxine (T4) in neuronal tissue, Decreased T4 in neuronal tissue, Decreased
KE 756 Hippocampal gene expression, Altered Hippocampal gene expression, Altered
KE 757 Hippocampal anatomy, Altered Hippocampal anatomy, Altered
KE 758 Hippocampal Physiology, Altered Hippocampal Physiology, Altered
AO 1101 Altered, Amphibian metamorphosis Altered, Amphibian metamorphosis

Relationships Between Two Key Events
(Including MIEs and AOs)

?

Network View

?

 

Stressors

?

Life Stage Applicability

?

Taxonomic Applicability

?

Sex Applicability

?

Overall Assessment of the AOP

?



Domain of Applicability

?


Essentiality of the Key Events

?


Evidence Assessment

?


Quantitative Understanding

?


Considerations for Potential Applications of the AOP (optional)

?



References

?