Key Event Relationships (KERs)

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Showing 1226 to 1250 of 2767 KERs

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ID Upstream Event Downstream Event Creation Date Last Updated AOPs
2800 2073: methemocyanin formation (decrease overall oxygen binding capacity) 2075: Hemocyanin Bohr effect decrease Nov 16, 2022 Nov 16, 2022
2067 1743: Increase plasma Ang II 1745: Increase,collagen synthesis Mar 17, 2020 Mar 17, 2020 None
2138 1743: Increase plasma Ang II 68: Accumulation, Collagen May 15, 2020 May 15, 2020 None
2435 1743: Increase plasma Ang II 1852: Increased Ang II type 1 receptor (AT1R) Jul 13, 2021 Jul 13, 2021
398 416: Increase proliferation, Leydig cell 415: Hyperplasia, Leydig cell Nov 29, 2016 Dec 3, 2016
2748 2054: Increase, impairment of cuticle sclerotization 990: Increase, Incomplete ecdysis Aug 28, 2022 Aug 28, 2022
2749 2055: Increase, pigmentation 990: Increase, Incomplete ecdysis Aug 28, 2022 Aug 28, 2022
2836 2098: Abnormal Neural Remodeling 341: Impairment, Learning and memory Jan 25, 2023 Mar 21, 2023
2091 1768: Increase, Abnormal osmoregulation 1769: Increase, Body fluid overload Apr 30, 2020 Apr 30, 2020
2181 1768: Increase, Abnormal osmoregulation 1809: Increase, Tissue/organ damage Nov 2, 2020 Nov 2, 2020 None
2736 2045: Increase, Alcohol dehydrogenase 748: Increased, Estrogen receptor (ER) activity Aug 28, 2022 Aug 28, 2022
1487 1384: Increase, ammonium (NH4+) 1382: Decrease, surfactant Apr 17, 2017 Apr 17, 2017
2910 2134: Increase, Androgen receptor 854: Alterations, Cellular proliferation / hyperplasia May 11, 2023 May 11, 2023
1473 1376: Increase, angiogenesis 1367: Inhibit, gastric ulcer formation Apr 17, 2017 Apr 17, 2017
2578 1376: Increase, angiogenesis 1193: N/A, Breast Cancer Feb 15, 2022 Feb 15, 2022 None
3137 1376: Increase, angiogenesis 1982: Metastasis, Breast Cancer Mar 5, 2024 Mar 5, 2024
1469 1365: Increase, Apoptosis 1366: Decrease, Oogenesis Apr 15, 2017 Apr 15, 2017
1596 1365: Increase, Apoptosis 1444: Increase, Follicular atresia Jun 29, 2017 Jun 29, 2017 None
1741 1365: Increase, Apoptosis 1521: Decrease, Growth May 24, 2018 May 24, 2018 None
1751 1365: Increase, Apoptosis 350: Increase, Mortality Jun 12, 2018 Jun 12, 2018
2075 1365: Increase, Apoptosis 1757: Reduce, Sperm count Apr 6, 2020 Apr 6, 2020
2185 1365: Increase, Apoptosis 1809: Increase, Tissue/organ damage Nov 2, 2020 Nov 2, 2020 None
2461 1365: Increase, Apoptosis 759: Increased, Kidney Failure Aug 5, 2021 Aug 5, 2021 None
2602 1365: Increase, Apoptosis 1978: Microcephaly Mar 17, 2022 Mar 17, 2022 None
2619 1365: Increase, Apoptosis 1798: Decreased spermatogenesis Mar 28, 2022 Mar 28, 2022