API

Stressor: 163

Title

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Tacrolimus

Stressor Overview

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AOPs Including This Stressor

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Events Including This Stressor

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Chemical Table

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User term DTXID Preferred name Casrn jchem_inchi_key indigo_inchi_key
Tacrolimus DTXSID5046354 Tacrolimus 104987-11-3 QJJXYPPXXYFBGM-LFZNUXCKSA-N QJJXYPPXXYFBGM-LFZNUXCKSA-N

AOP Evidence

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Inhibition of Calcineurin Activity Leading to Impaired T-Cell Dependent Antibody Response

There is no evidence text for this AOP




Event Evidence

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Binding, Immunophilins

There is no evidence text for this event.



Interference, nuclear localization of NFAT

There is no evidence text for this event.



Reduction, NFAT complex formation

There is no evidence text for this event.



Suppression, IL-2 and IL-4 production

There is no evidence text for this event.



Impairment, T-cell dependent antibody response

There is no evidence text for this event.




Stressor Info

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Chemical/Category Description

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Characterization of Exposure

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References

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