API

Stressor: 208

Title

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Gemfibrozil

Stressor Overview

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AOPs Including This Stressor

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AOP Name Evidence
PPARalpha-dependent liver cancer High

Events Including This Stressor

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Chemical Table

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User term DTXID Preferred name Casrn jchem_inchi_key indigo_inchi_key
Gemfibrozil DTXSID0020652 Gemfibrozil 25812-30-0 HEMJJKBWTPKOJG-UHFFFAOYSA-N HEMJJKBWTPKOJG-UHFFFAOYSA-N

AOP Evidence

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PPARalpha-dependent liver cancer

There is no evidence text for this AOP




Event Evidence

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Decreased, 11-ketotestosterone

Gemfibrozil reduces 11KT in the plasma of adult male medaka (Lee et al. 2019)



Decreased, cholesterol

Juvenile female rainbow trout have decreased cholesterol (including total, HDL, LDL, & VLDL) after exposure to gemfibrozil (Prindiville et al. 2011)

Male and female zebrafish fed gemfibrozil alone or in combination with atorvastatin have decreased cholesterol (Al-Habsi et al. 2016)




Stressor Info

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Chemical/Category Description

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Fibrate drug



Characterization of Exposure

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References

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