AOPs Including This Stressor
Events Including This Stressor
There is no evidence text for this AOP
Inhibition of RALDH2 causes reduced all-trans retinoic acid levels, leading to transposition of the great arteries
Bisdiamine (100 mg in 1ml of 1% gum-tragacanth, single dose of 200 mg/rat trough gastric tube) to strains Sprague-Dawley (SD) and Wister. Teratogenic effect of bis-diamine on embryonic hearts differed between strains. SD rats mostly showed aortic arch anomalies and agenesis of ductus arteries. In Wistar rats bis-diamine produced persistent truncus arteriosus and tetralogy of Fallot in embryos. Bis-diamine reduced the number of cNCCs in Wistar rat embryos when administered on ED10.5 and consequently resulted in conotruncal septation, persistent truncus arteriosus and tetralogy of Fallot (Fujino et al., 2005).