Stressor: 526
Title
SARS-CoV
Stressor Overview
AOPs Including This Stressor
Events Including This Stressor
Chemical Table
AOP Evidence
Binding of viral S-glycoprotein to ACE2 receptor leading to acute respiratory distress associated mortality
Cryo-EM structure of the SARS coronavirus spike glycoprotein in complex with its host cell receptor ACE2,https://doi.org/10.1371/journal.ppat.1007236
Kuba K, Imai Y, Rao S, Gao H, Guo F, Guan B, Huan Y, Yang P, Zhang Y, Deng W, Bao L, Zhang B, Liu G, Wang Z, Chappell M, Liu Y, Zheng D, Leibbrandt A, Wada T, Slutsky AS, Liu D, Qin C, Jiang C, Penninger JM (Aug 2005). "A crucial role of angiotensin converting enzyme 2 (ACE2) in SARS coronavirus-induced lung injury". Nature Medicine. 11 (8): 875–9. doi:10.1038/nm1267. PMID 16007097.
Dysregulated prolonged Toll Like Receptor 9 (TLR9) activation leading to Multi Organ Failure involving Acute Respiratory Distress Syndrome (ARDS)
Ng, L.F., Hibberd, M.L., Ooi, EE. et al. A human in vitro model system for investigating genome-wide host responses to SARS coronavirus infection. BMC Infect Dis 4, 34 (2004). https://doi.org/10.1186/1471-2334-4-34
Sars-CoV-2 Interferon-I antiviral response antagonism and increased viral production leading to viral infection proliferation
There is no evidence text for this AOP
Event Evidence
N/A, Neurodegeneration
There is no evidence text for this event.
Neuroinflammation
There is no evidence text for this event.
Encephalitis
There is no evidence text for this event.
Toll Like Receptor (TLR) Dysregulation
There is no evidence text for this event.
Fibrinolysis, decreased
There is no evidence text for this event.
Hyperinflammation
There is no evidence text for this event.
Dysregulation, ACE2 expression and activity
There is no evidence text for this event.