AOPs Including This Stressor
Events Including This Stressor
Binding of viral S-glycoprotein to ACE2 receptor leading to acute respiratory distress associated mortality
Cryo-EM structure of the SARS coronavirus spike glycoprotein in complex with its host cell receptor ACE2,https://doi.org/10.1371/journal.ppat.1007236
Kuba K, Imai Y, Rao S, Gao H, Guo F, Guan B, Huan Y, Yang P, Zhang Y, Deng W, Bao L, Zhang B, Liu G, Wang Z, Chappell M, Liu Y, Zheng D, Leibbrandt A, Wada T, Slutsky AS, Liu D, Qin C, Jiang C, Penninger JM (Aug 2005). "A crucial role of angiotensin converting enzyme 2 (ACE2) in SARS coronavirus-induced lung injury". Nature Medicine. 11 (8): 875–9. doi:10.1038/nm1267. PMID 16007097.
Dysregulated prolonged Toll Like Receptor 9 (TLR9) activation leading to Acute Respiratory Distress Syndrome (ARDS) and Multiple Organ Dysfunction (MOD)
Ng, L.F., Hibberd, M.L., Ooi, EE. et al. A human in vitro model system for investigating genome-wide host responses to SARS coronavirus infection. BMC Infect Dis 4, 34 (2004). https://doi.org/10.1186/1471-2334-4-34