Stressor: 571
Title
ferric nitrilotriacetate
Stressor Overview
AOPs Including This Stressor
AOP Name | Evidence |
---|---|
Chronic reactive oxygen species leading to human treatment-resistant gastric cancer | Not Specified |
Events Including This Stressor
Chemical Table
AOP Evidence
Chronic reactive oxygen species leading to human treatment-resistant gastric cancer
Carcinogenic iron(III)-nitrilotriacetate induces reactive oxygen species production via trasfer of an electron to molecular oxygen to form reactive oxygen species [Tsuchiya K, Akai K, Tokumura A, Abe S, Tamaki T, Takiguchi Y, Fukuzawa K. Biochim Biophys Acta. 2005 Aug 30;1725(1):111-9. doi: 10.1016/j.bbagen.2005.05.001, Akai K, Tsuchiya K, Tokumura A, Kogure K, Ueno S, Shibata A, Tamaki T, Fukuzawa K. Free Radic Res. 2004 Sep;38(9):951-62. doi: 10.1080/1071576042000261945.].
Event Evidence
Chronic reactive oxygen species
Iron(III)-nitrilotriacetate induces reactive oxygen species production via trasfer of an electron to molecular oxygen to form reactive oxygen species [Tsuchiya K, Akai K, Tokumura A, Abe S, Tamaki T, Takiguchi Y, Fukuzawa K. Biochim Biophys Acta. 2005 Aug 30;1725(1):111-9. doi: 10.1016/j.bbagen.2005.05.001, Akai K, Tsuchiya K, Tokumura A, Kogure K, Ueno S, Shibata A, Tamaki T, Fukuzawa K. Free Radic Res. 2004 Sep;38(9):951-62. doi: 10.1080/1071576042000261945.]
Up-regulation of Reactive Oxygen Species
There is no evidence text for this event.