API XML

Aop: 298

AOP Title

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Aryl hydrocarbon receptor effect on Mortality

Short name:

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Arh Mortality

Graphical Representation

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Click to download graphical representation template

Authors

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Point of Contact

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Arthur Author   (email point of contact)

Contributors

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  • Arthur Author

Status

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Author status OECD status OECD project SAAOP status
Under development: Not open for comment. Do not cite


This AOP was last modified on June 10, 2019 04:10

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Revision dates for related pages

Page Revision Date/Time
LSETAC Activation of aryl hydrocarbon receptor June 06, 2019 12:05
dimerization, AHR/ARNT September 16, 2017 10:14
reduced dimerization, ARNT/HIF1-alpha June 08, 2017 12:38
reduced production, VEGF September 16, 2017 10:16
Impairment, Endothelial network September 16, 2017 10:15
Altered, Cardiovascular development/function September 16, 2017 10:14
Increased early life stages mortality June 10, 2019 04:07
LSETAC AHR Activation leads to dimerization, AHR/ARNT June 10, 2019 04:06
dimerization, AHR/ARNT leads to reduced dimerization, ARNT/HIF1-alpha June 08, 2017 12:22
reduced dimerization, ARNT/HIF1-alpha leads to reduced production, VEGF June 12, 2017 14:07
reduced production, VEGF leads to Impairment, Endothelial network June 08, 2017 17:51
Impairment, Endothelial network leads to Altered, Cardiovascular development/function June 09, 2017 10:27
Altered, Cardiovascular development/function leads to Early life stages mortality, increased June 10, 2019 04:10

Abstract

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Background (optional)

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Summary of the AOP

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Events: Molecular Initiating Events (MIE)

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Key Events (KE)

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Adverse Outcomes (AO)

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Sequence Type Event ID Title Short name
MIE 1524 LSETAC Activation of aryl hydrocarbon receptor LSETAC AHR Activation
KE 944 dimerization, AHR/ARNT dimerization, AHR/ARNT
KE 945 reduced dimerization, ARNT/HIF1-alpha reduced dimerization, ARNT/HIF1-alpha
KE 948 reduced production, VEGF reduced production, VEGF
KE 110 Impairment, Endothelial network Impairment, Endothelial network
KE 317 Altered, Cardiovascular development/function Altered, Cardiovascular development/function
AO 1554 Increased early life stages mortality Early life stages mortality, increased

Relationships Between Two Key Events
(Including MIEs and AOs)

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Title Adjacency Evidence Quantitative Understanding
LSETAC AHR Activation leads to dimerization, AHR/ARNT adjacent High Not Specified
dimerization, AHR/ARNT leads to reduced dimerization, ARNT/HIF1-alpha adjacent Moderate Not Specified
reduced dimerization, ARNT/HIF1-alpha leads to reduced production, VEGF adjacent Moderate Not Specified
reduced production, VEGF leads to Impairment, Endothelial network adjacent High Not Specified
Impairment, Endothelial network leads to Altered, Cardiovascular development/function adjacent Moderate Not Specified
Altered, Cardiovascular development/function leads to Early life stages mortality, increased adjacent High Not Specified

Network View

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Stressors

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Life Stage Applicability

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Taxonomic Applicability

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Sex Applicability

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Overall Assessment of the AOP

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Domain of Applicability

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Essentiality of the Key Events

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Evidence Assessment

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Quantitative Understanding

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Considerations for Potential Applications of the AOP (optional)

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References

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