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Peroxisome proliferator-activated receptors γ inactivation leading to lung fibrosis
Point of Contact
- Jinhee Choi
- Brendan Ferreri-Hanberry
|Handbook Version||OECD status||OECD project|
This AOP was last modified on April 29, 2023 13:02
Revision dates for related pages
|Inactivation of PPARγ||December 26, 2017 02:12|
|Activation of TGF-β signaling||February 15, 2017 02:45|
|Collagen Deposition||February 15, 2017 02:55|
|Lung fibrosis||December 26, 2017 02:10|
|Increase, Inflammation||December 20, 2022 08:53|
|Induction, Epithelial Mesenchymal Transition||January 30, 2019 10:27|
|Inactivation of PPARγ leads to Activation of TGF-β signaling||February 15, 2017 02:57|
|Increase, Inflammation leads to EMT||January 30, 2019 10:58|
|Collagen Deposition leads to Lung fibrosis||February 15, 2017 02:58|
|Activation of TGF-β signaling leads to Increase, Inflammation||March 18, 2018 09:46|
|EMT leads to Collagen Deposition||November 20, 2018 20:57|
Pulmonary fibrosis is a respiratory disease in which scars are formed in the lung tissues, leading to serious breathing problems. It is an immunological process that is known to be regulated by the immune modulator Peroxisome proliferator-activated receptors γ (PPARγ) and transforming growth factor β (TGF-β). PPARγ ligands antagonize the profibrotic effects of TGF-β in which induce differentiation of fibroblasts to myofibroblasts, a critical effector cell in fibrosis. These sequential set of events are described in this Adverse Outcome Pathway (AOP). The molecular initiating event (MIE) is inactivation of PPARγ which leads to TGF-β activation, a key event (KE) at molecular level. Next, key event at cellular level is differentiation of Myofibroblast and expression of collagen gene by activated TGF-β signaling pathway. Differentiated myofibroblast subsequently produce α-smooth muscle actin (α-SMA) and overexpressed collagen deposits in lung tissue. This consecutive KE resulting in the acquisition of the accumulation of excess fibrous connective tissue, the adverse outcome on pulmonary fibrosis. Scar formation, the accumulation of excess fibrous connective tissue (the process called fibrosis), leads to thickening of the walls, and causes reduced oxygen supply in the blood. As a consequence patients suffer from perpetual shortness of breath.
AOP Development Strategy
Summary of the AOP
Molecular Initiating Events (MIE)
Key Events (KE)
Adverse Outcomes (AO)
|Type||Event ID||Title||Short name|
|MIE||1270||Inactivation of PPARγ||Inactivation of PPARγ|
|KE||1271||Activation of TGF-β signaling||Activation of TGF-β signaling|
|KE||149||Increase, Inflammation||Increase, Inflammation|
|KE||1275||Collagen Deposition||Collagen Deposition|
|KE||1457||Induction, Epithelial Mesenchymal Transition||EMT|
|AO||1276||Lung fibrosis||Lung fibrosis|
Relationships Between Two Key Events (Including MIEs and AOs)
Life Stage Applicability
|All life stages|
|Homo sapiens||Homo sapiens||NCBI|
Overall Assessment of the AOP
Domain of Applicability
Essentiality of the Key Events
Known Modulating Factors
Considerations for Potential Applications of the AOP (optional)
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