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Key Event Title
Inactivation of PPARγ
|Level of Biological Organization|
Key Event Components
Key Event Overview
AOPs Including This Key Event
|AOP Name||Role of event in AOP||Point of Contact||Author Status||OECD Status|
|PPARγ inactivation leading to lung fibrosis||MolecularInitiatingEvent||Brendan Ferreri-Hanberry (send email)||Under development: Not open for comment. Do not cite||Under Development|
|TLR4 activation, PPAR gamma activation and Pulmonary fibrosis||MolecularInitiatingEvent||Arthur Author (send email)||Under development: Not open for comment. Do not cite|
Key Event Description
Following pulmonary exposure, the stressor interacts with cellular membranes of alveolar macrophages, other inflammatory cells, epithelial cells and proteins (lung surfactants) in the lung space.
The stressor acts as an antagonist of PPARγ of epithelial and inflammatory cells in the lung.