API XML

Aop: 274

AOP Title

?


LSETAC DNA Alkylation

Short name:

?

LSETAC DNA alkylation leading to infertility

Graphical Representation

?

Click to download graphical representation template

Authors

?


Point of Contact

?


Arthur Author   (email point of contact)

Contributors

?


  • Arthur Author

Status

?

Author status OECD status OECD project SAAOP status
Under development: Not open for comment. Do not cite


This AOP was last modified on June 06, 2019 14:43

?

Revision dates for related pages

Page Revision Date/Time
LSETAC DNA Alkyl KE1 June 06, 2019 12:04
LSETAC June 06, 2019 12:09
LSETAC-DNA mutation June 06, 2019 14:37
AO: Decreased fertility (LSETAC) June 06, 2019 12:14
LSETAC Alkylation June 06, 2019 12:09
Alkylation of DNA leads to Saturation of AGT June 06, 2019 12:11
Alkylation of DNA leads to Increase in mutations June 06, 2019 14:42
Saturation of AGT leads to KE#2: Increase in DNA Adducts June 06, 2019 14:41
Alkylation of DNA leads to AO: Decreased fertility (LSETAC) June 06, 2019 14:43
KE#2: Increase in DNA Adducts leads to Increase in mutations June 06, 2019 12:13
Increase in mutations leads to AO: Decreased fertility (LSETAC) June 06, 2019 12:15

Abstract

?



Background (optional)

?



Summary of the AOP

?


Events: Molecular Initiating Events (MIE)

?

Key Events (KE)

?

Adverse Outcomes (AO)

?

Sequence Type Event ID Title Short name
MIE 1528 LSETAC Alkylation Alkylation of DNA
2 KE 1523 LSETAC DNA Alkyl KE1 Saturation of AGT
3 KE 1525 LSETAC KE#2: Increase in DNA Adducts
4 KE 1532 LSETAC-DNA mutation Increase in mutations
AO 1535 AO: Decreased fertility (LSETAC) AO: Decreased fertility (LSETAC)

Relationships Between Two Key Events
(Including MIEs and AOs)

?

Title Adjacency Evidence Quantitative Understanding
Alkylation of DNA leads to Saturation of AGT adjacent
Saturation of AGT leads to KE#2: Increase in DNA Adducts adjacent
KE#2: Increase in DNA Adducts leads to Increase in mutations adjacent
Increase in mutations leads to AO: Decreased fertility (LSETAC) adjacent
Alkylation of DNA leads to Increase in mutations non-adjacent
Alkylation of DNA leads to AO: Decreased fertility (LSETAC) non-adjacent

Network View

?

 

Stressors

?

Life Stage Applicability

?

Taxonomic Applicability

?

Sex Applicability

?

Overall Assessment of the AOP

?



Domain of Applicability

?


Essentiality of the Key Events

?


Evidence Assessment

?


Quantitative Understanding

?


Considerations for Potential Applications of the AOP (optional)

?



References

?