API
Event: 1558
Key Event Title
Collagen production, reduced
Short name
Reduced collagen productionBiological Context
| Level of Biological Organization |
|---|
| Tissue |
Organ term
Key Event Components
| Process | Object | Action |
|---|
Key Event Overview
AOPs Including This Key Event
| AOP Name | Role of event in AOP |
|---|---|
| HDAC inhibition leads to impeded craniofacial development | KeyEvent |
Stressors
Taxonomic Applicability
Life Stages
Sex Applicability
Key Event Description
Post-migratory cranial NCCs differentiate to give rise to chondrocytes which secrete collagen in order to form the cartilage structures which form the precursors of bony facial features (Bhatt et al., 2013).
How It Is Measured or Detected
Collagen expression is considered a marker for NCC differentiation into chondrocytes (Bhatt et al., 2013) and can be assessed in vivo by fluorescent microscopy using fluorescent collagen reporter zebrafish lines (Hammond and Schulte-Merker, 2009).
Domain of Applicability
References
Bhatt, S., Diaz, R., Trainor, P. a, Wu, D.K., Kelley, M.W., Tam, P.L., et al. (2013), Cold Spring Harb Perspect Biol 5: 1–20.
Hammond, C.L., and Schulte-Merker, S. (2009), Development 136: 3991–4000.