API XML

Aop: 315

AOP Title

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Estrogen leads to population decrease

Short name:

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Estrogen leads to Y

Graphical Representation

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Click to download graphical representation template

Authors

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Point of Contact

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Arthur Author   (email point of contact)

Contributors

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  • Arthur Author

Status

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Author status OECD status OECD project SAAOP status
Under development: Not open for comment. Do not cite


This AOP was last modified on June 10, 2019 04:11

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Revision dates for related pages

Page Revision Date/Time
Estrogen receptor (ER) Antagonism June 10, 2019 03:56
Reduction Vitellogenin synthesis in liver, Reduction June 10, 2019 04:03
Reduction, Plasma vitellogenin concentrations September 16, 2017 10:14
Reduction, Vitellogenin accumulation into oocytes and oocyte growth/development September 16, 2017 10:14
Reduction, Cumulative fecundity and spawning March 20, 2017 17:52
Decreased, Population trajectory April 18, 2017 16:19
ER antagonism leads to ccc June 10, 2019 04:10
ccc leads to Reduction, Plasma vitellogenin concentrations June 10, 2019 04:11

Abstract

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Background (optional)

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Summary of the AOP

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Events: Molecular Initiating Events (MIE)

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Key Events (KE)

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Adverse Outcomes (AO)

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Sequence Type Event ID Title Short name
MIE 1537 Estrogen receptor (ER) Antagonism ER antagonism
KE 1545 Reduction Vitellogenin synthesis in liver, Reduction ccc
KE 221 Reduction, Plasma vitellogenin concentrations Reduction, Plasma vitellogenin concentrations
KE 309 Reduction, Vitellogenin accumulation into oocytes and oocyte growth/development Reduction, Vitellogenin accumulation into oocytes and oocyte growth/development
KE 78 Reduction, Cumulative fecundity and spawning Reduction, Cumulative fecundity and spawning
AO 442 Decreased, Population trajectory Decreased, Population trajectory

Relationships Between Two Key Events
(Including MIEs and AOs)

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Title Adjacency Evidence Quantitative Understanding
ER antagonism leads to ccc adjacent
ccc leads to Reduction, Plasma vitellogenin concentrations adjacent

Network View

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Stressors

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Life Stage Applicability

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Taxonomic Applicability

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Sex Applicability

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Overall Assessment of the AOP

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Domain of Applicability

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Essentiality of the Key Events

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Evidence Assessment

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Quantitative Understanding

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Considerations for Potential Applications of the AOP (optional)

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References

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