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Key Event Title
Inhibition, Fatty Acid Beta Oxidation
|Level of Biological Organization|
Key Event Components
Key Event Overview
AOPs Including This Key Event
|AOP Name||Role of event in AOP||Point of Contact||Author Status||OECD Status|
|Inhibition fatty acid beta oxidation leading to nonalcoholic steatohepatisis (NASH)||MolecularInitiatingEvent||Arthur Author (send email)||Open for adoption|
Key Event Description
Biological state being measured: fatty acid beta oxidation
Biological compartment: mitochondria or peroxisome
General role in biology: Fatty acid beta oxidation (FABO) is the process by which fatty acids are metabolized into glucose for energy utilization.
How It Is Measured or Detected
Fatty acid beta oxidation (FABO) can be measured by:
1) Activity of the enzymes that perform FABO
2) Flourescence assays measuring extracellular oxygen consumption
3) Radiolabel assays using labeled palmitate
Domain of Applicability
This is a well-known metabolic pathway.