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Event: 1758
Key Event Title
Impaired, Spermatogenesis
Short name
Biological Context
Level of Biological Organization |
---|
Organ |
Organ term
Organ term |
---|
testis |
Key Event Components
Process | Object | Action |
---|---|---|
Abnormal spermatogenesis | Mature sperm cell | abnormal |
Key Event Overview
AOPs Including This Key Event
AOP Name | Role of event in AOP | Point of Contact | Author Status | OECD Status |
---|---|---|---|---|
PPARa Agonism Impairs Fish Reproduction | KeyEvent | Arthur Author (send email) | Open for citation & comment | |
11βHSD inhibition, decreased population trajectory | KeyEvent | Agnes Aggy (send email) | Under development: Not open for comment. Do not cite | Under Development |
Stressors
Taxonomic Applicability
Term | Scientific Term | Evidence | Link |
---|---|---|---|
Vertebrates | Vertebrates | High | NCBI |
Life Stages
Life stage | Evidence |
---|---|
Adult, reproductively mature | High |
Sex Applicability
Term | Evidence |
---|---|
Male | High |
Key Event Description
How It Is Measured or Detected
Domain of Applicability
Taxonomic Applicability: The relevance for invertebrates has not been evaluated.
Life Stage Applicability: Only applicable for sexually mature adults
Sex Applicability: Only applicable to males
Evidence for Perturbation by Stressor
Flutamide
Flutamide impairs spermatogenesis in adult male zebrafish (Yin et al., 2017)
Male fathead minnows exposed to flutamide show spermatocyte degredation and necrosis in their testis (Jensen et al., 2004)
Vinclozolin
A review of androgen signaling in male fish cites several studies showing vinclozolin decreases sperm quality (Golshan et al., 2019)
Bis(2-ethylhexyl) phthalate
A review of androgen signaling in male fish cites several studies showing DEHP decreases sperm quality (Golshan et al., 2019)
References
Golshan, M. & S.M.H. Alvai (2019) “Androgen signaling in male fishes: Examples of anti-androgenic chemicals that cause reproductive disorders”, Theriogenology, Vol. 139, Elsevier, pp. 58-71. https://doi.org/10.1016/j.theriogenology.2019.07.020
Jensen, K.M. et al. (2004) “Characterization of responses to the antiandrogen flutamide in a short-term reproduction assay with the fathead minnow”, Aquatic Toxicology, Vol. 70(2), Elsevier, pp. 99-110. https://doi.org/10.1016/j.aquatox.2004.06.012
Yin, P. et al. (2017) “Diethylstilbestrol, flutamide and their combination impaired the spermatogenesis of male adult zebrafish through disrupting HPG axis, meiosis and apoptosis”, Aquatic Toxicology, Vol. 185, Elsevier, pp. 129-137. https://doi.org/10.1016/j.aquatox.2017.02.013