API
Event: 66
Key Event Title
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Activation, ChREBP
Short name
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Activation, ChREBP
Biological Context
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| Level of Biological Organization |
| Molecular |
Cell term
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Organ term
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Key Event Components
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| Process |
Object |
Action |
| signaling |
carbohydrate-responsive element-binding protein |
increased |
Key Event Overview
AOPs Including This Key Event
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Stressors
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Taxonomic Applicability
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Life Stages
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Sex Applicability
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Key Event Description
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ChREBP is an LXR target that independently enhances the up-regulation of select lipogenic genes. The up-regulation of the ChREBP target gene is through liver-type pyruvate kinase (L-PK). Therefore, activation of LXR not only increases ChREBP mRNA via enhanced transcription but also modulates its activity [1]. In the liver, ChREBP mediates activation of several regulatory enzymes of glycolysis and lipogenesis including L-PK, acetyl CoA carboxylase (ACC), and fatty acid synthase (FAS). However, according to the study of Denechaud increase in the glucose flux in the cell is a prerequisite for ChREBP activation from T0901317 in mice [2].
How It Is Measured or Detected
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Domain of Applicability
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References
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- ↑ Cha & Repa 2007
- ↑ Denechaud et al. 2008