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Event: 66
Key Event Title
Activation, ChREBP
Short name
Biological Context
Level of Biological Organization |
---|
Molecular |
Cell term
Cell term |
---|
hepatocyte |
Organ term
Key Event Components
Process | Object | Action |
---|---|---|
signaling | carbohydrate-responsive element-binding protein | increased |
Key Event Overview
AOPs Including This Key Event
AOP Name | Role of event in AOP | Point of Contact | Author Status | OECD Status |
---|---|---|---|---|
LXR Activation to Liver Steatosis | KeyEvent | Agnes Aggy (send email) | Not under active development | |
NR1I3 suppression to steatosis | KeyEvent | Allie Always (send email) | Under Development: Contributions and Comments Welcome |
Taxonomic Applicability
Life Stages
Sex Applicability
Key Event Description
ChREBP is an LXR target that independently enhances the up-regulation of select lipogenic genes. The up-regulation of the ChREBP target gene is through liver-type pyruvate kinase (L-PK). Therefore, activation of LXR not only increases ChREBP mRNA via enhanced transcription but also modulates its activity [1]. In the liver, ChREBP mediates activation of several regulatory enzymes of glycolysis and lipogenesis including L-PK, acetyl CoA carboxylase (ACC), and fatty acid synthase (FAS). However, according to the study of Denechaud increase in the glucose flux in the cell is a prerequisite for ChREBP activation from T0901317 in mice [2].