AOP-Wiki

API

All Key Events

Showing 226 to 250 of 1781 Key Events

ID	Title	Event Component Count	Biological Organization	Created At	Last Updated	AOPs

459	Increased, Liver Steatosis Short Name Increased, Liver Steatosis	1	Organ	Nov 29, 2016	May 21, 2024	14 AOPs 58: NR1I3 (CAR) suppression leading to hepatic steatosis 60: NR1I2 (Pregnane X Receptor, PXR) activation leading to hepatic steatosis 61: NFE2L2/FXR activation leading to hepatic steatosis 62: AKT2 activation leading to hepatic steatosis 36: Peroxisomal Fatty Acid Beta-Oxidation Inhibition Leading to Steatosis 213: Inhibition of fatty acid beta oxidation leading to nonalcoholic steatohepatitis (NASH) 285: Inhibition of N-linked glycosylation leads to liver injury 318: Glucocorticoid Receptor activation leading to hepatic steatosis 517: Pregnane X Receptor (PXR) activation leads to liver steatosis 518: Liver X Receptor (LXR) activation leads to liver steatosis 529: Perfluorooctanesulfonic acid (PFOS) binding to peroxisome proliferator-activated receptors (PPARs) causes dysregulation of lipid metabolism and subsequent liver steatosis 232: NFE2/Nrf2 repression to steatosis 57: AhR activation leading to hepatic steatosis 494: AhR activation leading to liver fibrosis
460	Increased, Fatty acid uptake Short Name Increased, Fatty acid uptake	0	Cellular	Nov 29, 2016	Dec 3, 2016	None
461	Suppression, HNF4alpha Short Name Suppression, HNF4alpha	1	Molecular	Nov 29, 2016	Sep 16, 2017	59: HNF4alpha suppression leading to hepatic steatosis
462	Up Regulation, SCD-1 Short Name Up Regulation, SCD-1	1	Molecular	Nov 29, 2016	Sep 16, 2017	4 AOPs 58: NR1I3 (CAR) suppression leading to hepatic steatosis 60: NR1I2 (Pregnane X Receptor, PXR) activation leading to hepatic steatosis 57: AhR activation leading to hepatic steatosis 401: G protein-coupled estrogen receptor 1 (GPER) signal pathway in the lipid metabolism disrupting effects
463	Up Regulation, FAS Short Name Up Regulation, FAS	1	Molecular	Nov 29, 2016	Sep 16, 2017	58: NR1I3 (CAR) suppression leading to hepatic steatosis
465	Increased, FA Influx Short Name Increased, FA Influx	1	Cellular	Nov 29, 2016	Sep 16, 2017	3 AOPs 57: AhR activation leading to hepatic steatosis 60: NR1I2 (Pregnane X Receptor, PXR) activation leading to hepatic steatosis 58: NR1I3 (CAR) suppression leading to hepatic steatosis
466	Up Regulation, LDLR (low density lipoprotein receptor) Short Name	1	Molecular	Nov 29, 2016	Sep 16, 2017	57: AhR activation leading to hepatic steatosis
467	Increased, LDL uptake Short Name Increased, LDL uptake	1	Cellular	Nov 29, 2016	Sep 16, 2017	57: AhR activation leading to hepatic steatosis
468	Inhibition, PPAR alpha Short Name Inhibition, PPAR alpha	1	Molecular	Nov 29, 2016	Sep 16, 2017	58: NR1I3 (CAR) suppression leading to hepatic steatosis
470	Up Regulation, Acetyl-CoA carboxylase-1 (ACC-1) Short Name	1	Molecular	Nov 29, 2016	Sep 16, 2017	58: NR1I3 (CAR) suppression leading to hepatic steatosis
471	Inhibition, FoxA2 Short Name Inhibition, FoxA2	1	Molecular	Nov 29, 2016	Sep 16, 2017	60: NR1I2 (Pregnane X Receptor, PXR) activation leading to hepatic steatosis
472	Down Regulation, CPT1A Short Name Down Regulation, CPT1A	1	Molecular	Nov 29, 2016	Sep 16, 2017	2 AOPs 60: NR1I2 (Pregnane X Receptor, PXR) activation leading to hepatic steatosis 401: G protein-coupled estrogen receptor 1 (GPER) signal pathway in the lipid metabolism disrupting effects
474	Down Regulation, HMGCS2 Short Name Down Regulation, HMGCS2	1	Molecular	Nov 29, 2016	Sep 16, 2017	60: NR1I2 (Pregnane X Receptor, PXR) activation leading to hepatic steatosis
477	Decreased, Ketogenesis Short Name Decreased, Ketogenesis	1	Cellular	Nov 29, 2016	Sep 16, 2017	60: NR1I2 (Pregnane X Receptor, PXR) activation leading to hepatic steatosis
478	Activation, NRF2 Short Name Activation, NRF2	1	Molecular	Nov 29, 2016	Sep 16, 2017	61: NFE2L2/FXR activation leading to hepatic steatosis
479	Activation, NR1H4 Short Name Activation, NR1H4	1	Molecular	Nov 29, 2016	Sep 16, 2017	61: NFE2L2/FXR activation leading to hepatic steatosis
480	Activation, SHP Short Name Activation, SHP	1	Molecular	Nov 29, 2016	Sep 16, 2017	61: NFE2L2/FXR activation leading to hepatic steatosis
482	Decreased, DHB4/HSD17B4 Short Name Decreased, DHB4/HSD17B4	1	Molecular	Nov 29, 2016	Sep 16, 2017	61: NFE2L2/FXR activation leading to hepatic steatosis
483	Activation, LXR alpha Short Name Activation, LXR alpha	1	Molecular	Nov 29, 2016	Sep 16, 2017	61: NFE2L2/FXR activation leading to hepatic steatosis
484	Activation, AKT2 Short Name Activation, AKT2	1	Molecular	Nov 29, 2016	Sep 16, 2017	62: AKT2 activation leading to hepatic steatosis
486	systemic inflammation leading to hepatic steatosis Short Name inflammation	1	Organ	Nov 29, 2016	Feb 24, 2017	62: AKT2 activation leading to hepatic steatosis
488	Decrease, Ovulation Short Name Decrease, Ovulation	1	Organ	Nov 29, 2016	Sep 16, 2017	63: Cyclooxygenase inhibition leading to reproductive dysfunction
491	Clonal Expansion/Cell Proliferation, to form Altered Hepatic Foci (AHF) Short Name	1	Organ	Nov 29, 2016	Sep 16, 2017	46: AFB1: Mutagenic Mode-of-Action leading to Hepatocellular Carcinoma (HCC)
493	Increased, Insufficient repair or mis-repair of pro-mutagenic DNA adducts Short Name	1	Molecular	Nov 29, 2016	Sep 16, 2017	46: AFB1: Mutagenic Mode-of-Action leading to Hepatocellular Carcinoma (HCC)
494	Glucocorticoid Receptor Agonist, Activation Short Name GR Agonist, Activation	1	Molecular	Nov 29, 2016	Sep 16, 2017	64: Glucocorticoid Receptor (GR) Mediated Adult Leydig Cell Dysfunction Leading to Decreased Male Fertility