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All Key Events

Showing 726 to 750 of 1781 Key Events

ID	Title	Event Component Count	Biological Organization	Created At	Last Updated	AOPs

1153	Inhibition, Deiodinase 3 Short Name Inhibition, Deiodinase 3	1	Molecular	Nov 29, 2016	Dec 3, 2016	191: Type III iodotyrosine deiodinase (DIO3) inhibition leading to altered amphibian metamorphosis
1154	Increased, Triiodothyronine (T3) in tissues Short Name	1	Tissue	Nov 29, 2016	Dec 3, 2016	191: Type III iodotyrosine deiodinase (DIO3) inhibition leading to altered amphibian metamorphosis
1155	Inhibition, Pendrin Short Name Inhibition, Pendrin	1	Molecular	Nov 29, 2016	Dec 3, 2016	192: Pendrin inhibition leading to altered amphibian metamorphosis
1156	Inhibition, Dual oxidase Short Name Inhibition, Dual oxidase	1	Molecular	Nov 29, 2016	Dec 3, 2016	193: Dual oxidase (DUOX) inhibition leading to altered amphibian metamorphosis
1157	Activation, Hepatic nuclear receptor(s) Short Name Activation, Hepatic nuclear receptor(s)	1	Molecular	Nov 29, 2016	Sep 16, 2017	194: Hepatic nuclear receptor activation leading to altered amphibian metamorphosis
1158	Increased, Hepatic thyroid hormone uptake/transport Short Name	1	Tissue	Nov 29, 2016	Sep 16, 2017	4 AOPs 194: Hepatic nuclear receptor activation leading to altered amphibian metamorphosis 366: Competitive binding to thyroid hormone carrier protein transthyretin (TTR) leading to altered amphibian metamorphosis 367: Competitive binding to thyroid hormone carrier protein thyroid binding globulin (TBG) leading to altered amphibian metamorphosis 393: AOP for thyroid disorder caused by triphenyl phosphate via TRβ activation
1159	Increased, reuptake of 5-HT (5-hydroxytryptamine transporter; sodium-dependent serotonin transporter Short Name	0		Nov 29, 2016	Nov 29, 2016	None
1160	Increased, mantel display Short Name Increased, mantel display	0	Individual	Nov 29, 2016	Dec 3, 2016	None
1161	Increased, oocyte maturation Short Name Increased, oocyte maturation	1	Organ	Nov 29, 2016	Jan 17, 2017	195: 5-hydroxytryptamine transporter (5-HTT) inhibition leading to population increase
1162	Increased, cilia movement Short Name Increased, cilia movement	0	Cellular	Nov 29, 2016	Dec 3, 2016	None
1163	Increased, Reproductive Success Short Name Increased, Reproductive Success	1	Individual	Nov 29, 2016	Dec 3, 2016	2 AOPs 204: 5-hydroxytryptamine transporter inhibition leading to increased reproductive success and population increase 195: 5-hydroxytryptamine transporter (5-HTT) inhibition leading to population increase
1164	Increased, Population Short Name Increased, Population	1	Population	Nov 29, 2016	Dec 3, 2016	2 AOPs 195: 5-hydroxytryptamine transporter (5-HTT) inhibition leading to population increase 204: 5-hydroxytryptamine transporter inhibition leading to increased reproductive success and population increase
1165	Vitamin K inhibition, gamma-carboxylation of glutamate to Gla residues reduced in bone proteins e.g., periostin Short Name	0		Nov 29, 2016	Nov 29, 2016	None
1166	Increased, water pumping Short Name Increased, water pumping	0	Tissue	Nov 29, 2016	Dec 3, 2016	None
1167	induced, parturition Short Name induced, parturition	0	Individual	Nov 29, 2016	Dec 3, 2016	None
1168	Undercarboxylation of osteocalcin , Affects bone formation (osteoblast-osteoclast interaction, bone resorption) and glucose and lipid hoemostasis Short Name	0		Nov 29, 2016	Nov 29, 2016	None
1169	Anticoagulant rodenticide interferes with carboxylation of Gla proteins in bone, Impairment of post-translational modification (carboxylation) of osteocalcin Short Name	2	Molecular	Nov 29, 2016	Dec 3, 2016	187: Anticoagulant rodenticide inhibition of vitamin K epoxide reductase resulting coagulopathy and hemorrhage
1170	Increase, Phenotypic enzyme activity Short Name Increase, Phenotypic enzyme activity	0	Cellular	Nov 29, 2016	Dec 28, 2020	37: PPARα activation leading to hepatocellular adenomas and carcinomas in rodents
1171	Increase, Clonal Expansion of Altered Hepatic Foci Short Name	0	Cellular	Nov 29, 2016	Jan 6, 2021	37: PPARα activation leading to hepatocellular adenomas and carcinomas in rodents
1172	Increased activation, Nuclear factor kappa B (NF-kB) Short Name	1	Cellular	Nov 29, 2016	Aug 27, 2023	4 AOPs 382: Angiotensin II type 1 receptor (AT1R) agonism leading to lung fibrosis 377: Dysregulated prolonged Toll Like Receptor 9 (TLR9) activation leading to Multi Organ Failure involving Acute Respiratory Distress Syndrome (ARDS) 319: Binding to ACE2 leading to lung fibrosis 443: DNA damage and mutations leading to Metastatic Breast Cancer
1173	Increase, Peroxisomal Fatty Acid Beta Oxidation of Fatty Acids Short Name	0	Molecular	Nov 29, 2016	Dec 3, 2016	None
1174	Activation, NADPH Oxidase Short Name Activation, NADPH Oxidase	1	Molecular	Nov 29, 2016	Sep 16, 2017	207: NADPH oxidase and P38 MAPK activation leading to reproductive failure in Caenorhabditis elegans
1175	Increase, Genes involved in fatty acid oxidation Short Name	0	Cellular	Nov 29, 2016	Dec 3, 2016	None
1176	Decreased, sodium conductance 2 Short Name Decreased, sodium conductance 2	1	Cellular	Nov 29, 2016	Dec 3, 2016	197: Sodium channel (Nav1.1) inhibition leading to population decline
1177	Decreased, Ionotropic GABA receptor chloride channel conductance Short Name	0	Cellular	Nov 29, 2016	Dec 3, 2016	471: Various neuronal effects induced by elavl3, sox10, and mbp