AOP-Wiki

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All Key Events

Showing 751 to 775 of 1781 Key Events

ID	Title	Event Component Count	Biological Organization	Created At	Last Updated	AOPs

1178	Decreased, Chloride conductance Short Name Decreased, Chloride conductance	0		Nov 29, 2016	Nov 29, 2016	None
1179	Decreased, GABA release Short Name Decreased, GABA release	1	Cellular	Nov 29, 2016	Dec 3, 2016	197: Sodium channel (Nav1.1) inhibition leading to population decline
1180	Estrogen receptor activation, Short Name Estrogen receptor activation,	0		Nov 29, 2016	Nov 29, 2016	None
1181	Activation, Estrogen receptor Short Name Activation, Estrogen receptor	1	Molecular	Nov 29, 2016	Sep 16, 2017	200: Estrogen receptor activation leading to breast cancer
1182	Increase, Cell Proliferation (Epithelial Cells) Short Name	1	Cellular	Nov 29, 2016	May 8, 2019	3 AOPs 200: Estrogen receptor activation leading to breast cancer 294: Increased reactive oxygen and nitrogen species (RONS) leading to increased risk of breast cancer 293: Increased DNA damage leading to increased risk of breast cancer
1183	Decreased, Apoptosis (Epithelial Cells) Short Name Decreased, Apoptosis (Epithelial Cells)	1	Cellular	Nov 29, 2016	Sep 16, 2017	2 AOPs 200: Estrogen receptor activation leading to breast cancer 495: Androgen receptor activation leading to prostate cancer
1184	Dysfunction, Mitochondrial Dynamics Short Name Dysfunction, Mitochondrial Dynamics	0		Nov 29, 2016	Nov 29, 2016	None
1187	Increased, ER binding to DNA (classical pathway) Short Name	1	Molecular	Nov 29, 2016	Sep 16, 2017	200: Estrogen receptor activation leading to breast cancer
1188	Increased, ER binding to T.F. to DNA (non-classical pathway) Short Name	1	Molecular	Nov 29, 2016	Sep 16, 2017	200: Estrogen receptor activation leading to breast cancer
1189	Increased, Proliferation (Endothelial cells) Short Name	1	Cellular	Nov 29, 2016	Sep 16, 2017	200: Estrogen receptor activation leading to breast cancer
1190	Increased, Migration (Endothelial Cells) Short Name	1	Cellular	Nov 29, 2016	Feb 29, 2024	2 AOPs 200: Estrogen receptor activation leading to breast cancer 439: Activation of the AhR leading to metastatic breast cancer
1191	Increased, Non-genomic signaling Short Name Increased, Non-genomic signaling	1	Cellular	Nov 29, 2016	Sep 16, 2017	200: Estrogen receptor activation leading to breast cancer
1192	Increased, Ductal Hyperplasia Short Name Increased, Ductal Hyperplasia	1	Tissue	Nov 29, 2016	Sep 16, 2017	3 AOPs 200: Estrogen receptor activation leading to breast cancer 293: Increased DNA damage leading to increased risk of breast cancer 294: Increased reactive oxygen and nitrogen species (RONS) leading to increased risk of breast cancer
1193	N/A, Breast Cancer Short Name N/A, Breast Cancer	1	Individual	Nov 29, 2016	Feb 29, 2024	3 AOPs 200: Estrogen receptor activation leading to breast cancer 293: Increased DNA damage leading to increased risk of breast cancer 294: Increased reactive oxygen and nitrogen species (RONS) leading to increased risk of breast cancer
1194	Increase, DNA damage Short Name Increase, DNA Damage	1	Molecular	Nov 29, 2016	May 8, 2019	11 AOPs 200: Estrogen receptor activation leading to breast cancer 293: Increased DNA damage leading to increased risk of breast cancer 294: Increased reactive oxygen and nitrogen species (RONS) leading to increased risk of breast cancer 396: Deposition of ionizing energy leads to population decline via impaired meiosis 432: Deposition of Energy by Ionizing Radiation leading to Acute Myeloid Leukemia 388: Deposition of ionising energy leading to population decline via programmed cell death 435: Deposition of ionising energy leads to population decline via pollen abnormal 441: Ionizing radiation-induced DNA damage leads to microcephaly via apoptosis and premature cell differentiation 444: Ionizing radiation leads to reduced reproduction in Eisenia fetida via reduced spermatogenesis and cocoon hatchability 423: Toxicological mechanisms of hepatocyte apoptosis through the PARP1 dependent cell death pathway 476: Adverse Outcome Pathways diagram related to PBDEs associated male reproductive toxicity
1195	modulation, Extracellular Matrix Composition Short Name	1	Cellular	Nov 29, 2016	Sep 16, 2017	200: Estrogen receptor activation leading to breast cancer
1196	Increased, Invasion Short Name Increased, Invasion	1	Cellular	Nov 29, 2016	Feb 29, 2024	3 AOPs 200: Estrogen receptor activation leading to breast cancer 439: Activation of the AhR leading to metastatic breast cancer 495: Androgen receptor activation leading to prostate cancer
1197	Activation, Fibroblasts Short Name Activation, Fibroblasts	1	Cellular	Nov 29, 2016	Sep 16, 2017	2 AOPs 200: Estrogen receptor activation leading to breast cancer 481: AOPs of amorphous silica nanoparticles: ROS-mediated oxidative stress increased respiratory dysfunction and diseases.
1198	Activation, Macrophages Short Name Activation, Macrophages	1	Cellular	Nov 29, 2016	Sep 16, 2017	2 AOPs 200: Estrogen receptor activation leading to breast cancer 481: AOPs of amorphous silica nanoparticles: ROS-mediated oxidative stress increased respiratory dysfunction and diseases.
1199	Binding of FK506 to FKBP12, Short Name Binding of FK506 to FKBP12,	0		Nov 29, 2016	Nov 29, 2016	None
1200	Binding of FK506 to FKBP12, Formation Short Name Binding of FK506 to FKBP12, Formation	0		Nov 29, 2016	Nov 29, 2016	None
1201	Binding, Immunophilins Short Name Binding, Immunophilins	1	Molecular	Nov 29, 2016	Oct 17, 2017	None
1202	Suppression, IL-2 and IL-4 production Short Name Suppression, IL-2 and IL-4 production	2	Cellular	Nov 29, 2016	Jun 27, 2021	154: Inhibition of Calcineurin Activity Leading to Impaired T-Cell Dependent Antibody Response
1203	Suppression, Suppression of production of cytotoxic T-cells Short Name	0	Tissue	Nov 29, 2016	Dec 3, 2016	None
1204	Suppression, Suppression of T-cell dependent antibody production Short Name	0	Cellular	Nov 29, 2016	Dec 3, 2016	None