AOP-Wiki

API

All Key Events

Showing 351 to 375 of 1781 Key Events

ID	Title	Event Component Count	Biological Organization	Created At	Last Updated	AOPs

674	Reduced, Ability to attract spawning mates Short Name	1	Individual	Nov 29, 2016	Dec 3, 2016	2 AOPs 100: Cyclooxygenase inhibition leading to reproductive dysfunction via inhibition of female spawning behavior 101: Cyclooxygenase inhibition leading to reproductive dysfunction via inhibition of pheromone release
675	Reduced, Reproductive Success Short Name Reduced, Reproductive Success	2	Individual	Nov 29, 2016	Dec 3, 2016	5 AOPs 100: Cyclooxygenase inhibition leading to reproductive dysfunction via inhibition of female spawning behavior 101: Cyclooxygenase inhibition leading to reproductive dysfunction via inhibition of pheromone release 63: Cyclooxygenase inhibition leading to reproductive dysfunction 102: Cyclooxygenase inhibition leading to reproductive dysfunction via interference with meiotic prophase I /metaphase I transition 103: Cyclooxygenase inhibition leading to reproductive dysfunction via interference with spindle assembly checkpoint
678	Reduced, Pheromone release Short Name Reduced, Pheromone release	1	Individual	Nov 29, 2016	Dec 3, 2016	101: Cyclooxygenase inhibition leading to reproductive dysfunction via inhibition of pheromone release
679	Decline, Population trajectory Short Name Decline, Population trajectory	1	Population	Nov 29, 2016	Dec 3, 2016	309: Luteinizing hormone receptor antagonism leading to reproductive dysfunction
681	Decreased, Prostaglandin F2alpha synthesis, ovary Short Name	1	Organ	Nov 29, 2016	Sep 16, 2017	101: Cyclooxygenase inhibition leading to reproductive dysfunction via inhibition of pheromone release
682	Generation, Amplified excitatory postsynaptic potential (EPSP) Short Name	1	Cellular	Nov 29, 2016	May 18, 2018	10: Binding to the picrotoxin site of ionotropic GABA receptors leading to epileptic seizures in adult brain
685	Reduced, Prostaglandins, ovary Short Name Reduced, Prostaglandins, ovary	1	Organ	Nov 29, 2016	Sep 16, 2017	63: Cyclooxygenase inhibition leading to reproductive dysfunction
687	Reduced, Prostaglandin E2 concentration, hypothalamus Short Name	1	Tissue	Nov 29, 2016	Sep 16, 2017	2 AOPs 102: Cyclooxygenase inhibition leading to reproductive dysfunction via interference with meiotic prophase I /metaphase I transition 103: Cyclooxygenase inhibition leading to reproductive dysfunction via interference with spindle assembly checkpoint
689	Reduced, Gonadotropin releasing hormone, hypothalamus Short Name	1	Tissue	Nov 29, 2016	Sep 16, 2017	2 AOPs 102: Cyclooxygenase inhibition leading to reproductive dysfunction via interference with meiotic prophase I /metaphase I transition 103: Cyclooxygenase inhibition leading to reproductive dysfunction via interference with spindle assembly checkpoint
690	Reduced, Luteinizing hormone (LH), plasma Short Name	1	Tissue	Nov 29, 2016	Sep 16, 2017	2 AOPs 102: Cyclooxygenase inhibition leading to reproductive dysfunction via interference with meiotic prophase I /metaphase I transition 103: Cyclooxygenase inhibition leading to reproductive dysfunction via interference with spindle assembly checkpoint
691	Reduced, Maturation inducing steroid, plasma Short Name	1	Tissue	Nov 29, 2016	Sep 16, 2017	2 AOPs 102: Cyclooxygenase inhibition leading to reproductive dysfunction via interference with meiotic prophase I /metaphase I transition 103: Cyclooxygenase inhibition leading to reproductive dysfunction via interference with spindle assembly checkpoint
692	Reduced, Maturation inducing steroid receptor signalling, oocyte Short Name	2	Tissue	Nov 29, 2016	Sep 16, 2017	2 AOPs 102: Cyclooxygenase inhibition leading to reproductive dysfunction via interference with meiotic prophase I /metaphase I transition 103: Cyclooxygenase inhibition leading to reproductive dysfunction via interference with spindle assembly checkpoint
693	Increased, cyclic adenosine monophosphate Short Name	1	Tissue	Nov 29, 2016	Dec 3, 2016	102: Cyclooxygenase inhibition leading to reproductive dysfunction via interference with meiotic prophase I /metaphase I transition
694	Reduced, Meiotic prophase I/metaphase I transition, oocyte Short Name	1	Cellular	Nov 29, 2016	Sep 16, 2017	102: Cyclooxygenase inhibition leading to reproductive dysfunction via interference with meiotic prophase I /metaphase I transition
695	Upregulated, Spindle assembly checkpoint protein Mad2-oocyte Short Name	1	Molecular	Nov 29, 2016	Sep 16, 2017	103: Cyclooxygenase inhibition leading to reproductive dysfunction via interference with spindle assembly checkpoint
696	Increased, Chromosome misseggregation Short Name Increased, Chromosome misseggregation	1	Cellular	Nov 29, 2016	Sep 16, 2017	103: Cyclooxygenase inhibition leading to reproductive dysfunction via interference with spindle assembly checkpoint
697	impaired, ion channels Short Name impaired, ion channels	2	Cellular	Nov 29, 2016	Dec 3, 2016	104: Altered ion channel activity leading impaired heart function
698	Altered, Action Potential Short Name Altered, Action Potential	1	Cellular	Nov 29, 2016	Mar 31, 2022	104: Altered ion channel activity leading impaired heart function
699	Increased, cardiac arrthymia Short Name Increased, cardiac arrthymia	1	Organ	Nov 29, 2016	Sep 16, 2017	104: Altered ion channel activity leading impaired heart function
708	Increased, Accumulation of alpha2u microglobulin (proximal tubular epithelium) Short Name	1	Tissue	Nov 29, 2016	Sep 16, 2017	105: Alpha2u-microglobulin cytotoxicity leading to renal tubular adenomas and carcinomas (in male rat)
709	Increase, Cytotoxicity (renal tubular cell) Short Name	1	Cellular	Nov 29, 2016	Mar 3, 2022	5 AOPs 105: Alpha2u-microglobulin cytotoxicity leading to renal tubular adenomas and carcinomas (in male rat) 256: Inhibition of mitochondrial DNA polymerase gamma leading to kidney toxicity 257: Receptor mediated endocytosis and lysosomal overload leading to kidney toxicity 258: Renal protein alkylation leading to kidney toxicity 437: Inhibition of mitochondrial electron transport chain (ETC) complexes leading to kidney toxicity
710	Increase, Regenerative cell proliferation (tubular epithelial cells) Short Name	1	Cellular	Nov 29, 2016	Sep 16, 2017	2 AOPs 105: Alpha2u-microglobulin cytotoxicity leading to renal tubular adenomas and carcinomas (in male rat) 116: Cytotoxicity leading to renal tubular adenomas and carcinomas (in male rat)
713	Increase, Adenomas/carcinomas (renal tubular) Short Name	3	Tissue	Nov 29, 2016	Sep 16, 2017	2 AOPs 105: Alpha2u-microglobulin cytotoxicity leading to renal tubular adenomas and carcinomas (in male rat) 116: Cytotoxicity leading to renal tubular adenomas and carcinomas (in male rat)
714	Increased, Binding of chemicals to 2u (serum) Short Name	1	Molecular	Nov 29, 2016	Sep 16, 2017	105: Alpha2u-microglobulin cytotoxicity leading to renal tubular adenomas and carcinomas (in male rat)
715	Activation, Constitutive androstane receptor Short Name	1	Molecular	Nov 29, 2016	Jun 28, 2018	107: Constitutive androstane receptor activation leading to hepatocellular adenomas and carcinomas in the mouse and the rat