AOP-Wiki

API

All Key Events

Showing 501 to 525 of 1781 Key Events

ID	Title	Event Component Count	Biological Organization	Created At	Last Updated	AOPs

878	Inhibition, SREBP1c Short Name Inhibition, SREBP1c	1	Molecular	Nov 29, 2016	Sep 16, 2017	61: NFE2L2/FXR activation leading to hepatic steatosis
879	Activation, MTTP Short Name Activation, MTTP	1	Cellular	Nov 29, 2016	Sep 16, 2017	61: NFE2L2/FXR activation leading to hepatic steatosis
880	Increased, ApoB100 Short Name Increased, ApoB100	1	Tissue	Nov 29, 2016	Sep 16, 2017	61: NFE2L2/FXR activation leading to hepatic steatosis
881	Increased, Triglyceride Short Name Increased, Triglyceride	1	Cellular	Nov 29, 2016	Sep 16, 2017	61: NFE2L2/FXR activation leading to hepatic steatosis
885	Increase, Cancer Short Name Increase, Cancer	1	Tissue	Nov 29, 2016	Aug 22, 2023	4 AOPs 141: Alkylation of DNA leading to cancer 2 139: Alkylation of DNA leading to cancer 1 505: Reactive Oxygen Species (ROS) formation leads to cancer via inflammation pathway 513: Reactive Oxygen (ROS) formation leads to cancer via Peroxisome proliferation-activated receptor (PPAR) pathway
887	Inhibition, NADH-ubiquinone oxidoreductase (complex I) Short Name	1	Cellular	Nov 29, 2016	Mar 12, 2018	3 AOPs 3: Inhibition of the mitochondrial complex I of nigro-striatal neurons leads to parkinsonian motor deficits 276: Inhibition of complex I of the electron transport chain leading to chemical induced Fanconi syndrome 273: Mitochondrial complex inhibition leading to liver injury
888	Binding of inhibitor, NADH-ubiquinone oxidoreductase (complex I) Short Name	1	Molecular	Nov 29, 2016	Mar 28, 2018	3 AOPs 3: Inhibition of the mitochondrial complex I of nigro-striatal neurons leads to parkinsonian motor deficits 276: Inhibition of complex I of the electron transport chain leading to chemical induced Fanconi syndrome 273: Mitochondrial complex inhibition leading to liver injury
889	Impaired, Proteostasis Short Name Impaired, Proteostasis	1	Cellular	Nov 29, 2016	Mar 15, 2018	2 AOPs 3: Inhibition of the mitochondrial complex I of nigro-striatal neurons leads to parkinsonian motor deficits 273: Mitochondrial complex inhibition leading to liver injury
890	Degeneration of dopaminergic neurons of the nigrostriatal pathway Short Name	1	Organ	Nov 29, 2016	Mar 15, 2018	2 AOPs 3: Inhibition of the mitochondrial complex I of nigro-striatal neurons leads to parkinsonian motor deficits 471: Various neuronal effects induced by elavl3, sox10, and mbp
896	Parkinsonian motor deficits Short Name Parkinsonian motor deficits	1	Individual	Nov 29, 2016	Mar 12, 2018	3 AOPs 3: Inhibition of the mitochondrial complex I of nigro-striatal neurons leads to parkinsonian motor deficits 464: Calcium overload in dopaminergic neurons of the substantia nigra leading to parkinsonian motor deficits 471: Various neuronal effects induced by elavl3, sox10, and mbp
898	Disruption, Lysosome Short Name Disruption, Lysosome	1	Cellular	Nov 29, 2016	Nov 12, 2018	3 AOPs 257: Receptor mediated endocytosis and lysosomal overload leading to kidney toxicity 144: Endocytic lysosomal uptake leading to liver fibrosis 530: Endocytotic lysosomal uptake leads to intestinal barrier disruption
901	Infiltration, Inflammatory cells Short Name Infiltration, Inflammatory cells	1	Tissue	Nov 29, 2016	Sep 16, 2017	None
902	Inflammation, Liver Short Name Inflammation, Liver	1	Organ	Nov 29, 2016	Sep 16, 2017	377: Dysregulated prolonged Toll Like Receptor 9 (TLR9) activation leading to Multi Organ Failure involving Acute Respiratory Distress Syndrome (ARDS)
907	Infiltration, Inflammatory cytokines Short Name Infiltration, Inflammatory cytokines	0		Nov 29, 2016	Nov 29, 2016	None
913	Activation, Epidermal Growth Factor Receptor Short Name	0		Nov 29, 2016	Nov 29, 2016	None
914	Decrease, Apoptosis of ciliated epithelial cells Short Name Decreased ciliated cell apoptosis	1	Cellular	Nov 29, 2016	Aug 17, 2021	None
919	Occurrence, Transdifferentiation of ciliated epithelial cells Short Name	1	Cellular	Nov 29, 2016	Aug 17, 2021	None
920	Occurrence, Metaplasia of goblet cells Short Name Goblet cell metaplasia	1	Tissue	Nov 29, 2016	Aug 23, 2021	None
921	Occurrence, Hyperplasia of goblet cells Short Name Goblet cell hyperplasia	1	Tissue	Nov 29, 2016	Sep 21, 2021	None
923	Increase, Proliferation of goblet cells Short Name Increased goblet cell proliferation	1	Cellular	Nov 29, 2016	Aug 20, 2021	None
924	Activation, Sp1 Short Name Activation, Sp1	1	Molecular	Nov 29, 2016	Aug 20, 2021	None
926	Oxidation, Glutathione (To be considered with MIE) Short Name Oxidation, Glutathione	1	Molecular	Nov 29, 2016	Nov 9, 2017	2 AOPs 284: Binding of electrophilic chemicals to SH(thiol)-group of proteins and /or to seleno-proteins involved in protection against oxidative stress leads to chronic kidney disease 413: Oxidation and antagonism of reduced glutathione leading to mortality via acute renal failure
927	KE1 : S-Glutathionylation, eNOS Short Name S-Glutathionylation, eNOS	2	Molecular	Nov 29, 2016	Nov 20, 2017	149: Peptide Oxidation Leading to Hypertension
932	KE4 : Uncoupling, eNOS Short Name Uncoupling, eNOS	1	Cellular	Nov 29, 2016	Nov 9, 2017	2 AOPs 149: Peptide Oxidation Leading to Hypertension 511: The AOP framework on ROS-mediated oxidative stress induced vascular disrupting effects
933	KE6 : Depletion, Nitric Oxide Short Name Depletion, Nitric Oxide	1	Cellular	Nov 29, 2016	Nov 9, 2017	149: Peptide Oxidation Leading to Hypertension