AOP-Wiki

API

All Key Events

Showing 551 to 575 of 1781 Key Events

ID	Title	Event Component Count	Biological Organization	Created At	Last Updated	AOPs

972	Decreased fertility, Reduced number of oocytes ovulated Short Name	1	Individual	Nov 29, 2016	Dec 3, 2016	153: Aromatase Inhibition leading to Ovulation Inhibition and Decreased Fertility in Female Rats
973	KE5 : Decrease, AKT/eNOS activity Short Name Decrease, AKT/eNOS activity	2	Cellular	Nov 29, 2016	Nov 9, 2017	149: Peptide Oxidation Leading to Hypertension
974	The binding of FK506 with FKBP12, Short Name The binding of FK506 with FKBP12,	0		Nov 29, 2016	Nov 29, 2016	None
975	The binding of FK506 with FKBP12, The binding of FK506 with FKBP12 Short Name	0		Nov 29, 2016	Nov 29, 2016	None
976	Formation, The binding of FK506 with FKBP12 Short Name	0	Molecular	Nov 29, 2016	Dec 3, 2016	None
977	Binding, Binding of calcineurin with FK506-FKBP complexes Short Name	0		Nov 29, 2016	Nov 29, 2016	None
978	Activation, Suppression of NFAT activation and hindrance of nuclear localization Short Name	0	Molecular	Nov 29, 2016	Dec 3, 2016	None
979	Interference, nuclear localization of NFAT Short Name	1	Molecular	Nov 29, 2016	Jul 2, 2021	154: Inhibition of Calcineurin Activity Leading to Impaired T-Cell Dependent Antibody Response
980	Inhibition, Calcineurin Activity Short Name Inhibition, Calcineurin Activity	2	Molecular	Nov 29, 2016	Jun 27, 2021	154: Inhibition of Calcineurin Activity Leading to Impaired T-Cell Dependent Antibody Response
981	Reduction, NFAT/AP-1 complex formation Short Name Reduction, NFAT/AP-1 complex formation	2	Cellular	Nov 29, 2016	Jun 27, 2021	154: Inhibition of Calcineurin Activity Leading to Impaired T-Cell Dependent Antibody Response
982	Suppression, Suppression in mixed lymphocyte reaction (MLR) Short Name	0	Cellular	Nov 29, 2016	Dec 3, 2016	None
983	Suppression, Suppression of T-cell dependent antibody response (TDAR) Short Name	0	Cellular	Nov 29, 2016	Dec 3, 2016	None
984	Impairment, T-cell dependent antibody response Short Name	1	Individual	Nov 29, 2016	Feb 19, 2023	2 AOPs 154: Inhibition of Calcineurin Activity Leading to Impaired T-Cell Dependent Antibody Response 277: Impaired IL-1R1 signaling leading to Impaired T-Cell Dependent Antibody Response
985	Relief, Relief of atopic dermatitis Short Name Relief, Relief of atopic dermatitis	0	Individual	Nov 29, 2016	Dec 3, 2016	None
986	Impairment of TDAR Short Name Impairment of TDAR	0	Individual	Nov 29, 2016	Mar 2, 2023	None
987	Metaplasia of goblet cells Short Name Metaplasia of goblet cells	0	Molecular	Nov 29, 2016	Oct 5, 2020	None
988	Decrease, Circulating ecdysis triggering hormone Short Name Decrease, Circulating ETH	1	Tissue	Nov 29, 2016	May 24, 2018	4: Ecdysone receptor agonism leading to incomplete ecdysis associated mortality
989	Decreased, synthesis and secretion of molting fluid proteases Short Name	0		Nov 29, 2016	Nov 29, 2016	None
990	Increase, Incomplete ecdysis Short Name Increase, Incomplete ecdysis	1	Individual	Nov 29, 2016	May 24, 2018	3 AOPs 4: Ecdysone receptor agonism leading to incomplete ecdysis associated mortality 466: Doda decarboxylase leading to mortality 467: Knickkopf leading to mortality
992	Decreased, Population 2 Short Name Decreased, Population 2	0		Nov 29, 2016	Nov 29, 2016	None
993	Decrease, Abdominal muscle contraction Short Name Decrease, Abdominal muscle contraction	1	Tissue	Nov 29, 2016	May 24, 2018	4: Ecdysone receptor agonism leading to incomplete ecdysis associated mortality
994	Decreased, Synthesis of molting fluid proteases Short Name	0	Tissue	Nov 29, 2016	Dec 3, 2016	None
996	Decrease, Digestion of old cuticle Short Name Decrease, Digestion of old cuticle	0	Organ	Nov 29, 2016	Oct 21, 2020	2 AOPs 358: Chitinase inhibition leading to mortality 359: Chitobiase inhibition leading to mortality
997	Decreased, Population size Short Name Decreased, Population size	0	Population	Nov 29, 2016	Dec 3, 2016	396: Deposition of ionizing energy leads to population decline via impaired meiosis
998	Binding of antagonist, PPAR alpha Short Name Binding of antagonist, PPAR alpha	1	Molecular	Nov 29, 2016	Sep 16, 2017	6: Antagonist binding to PPARα leading to body-weight loss