AOP-Wiki

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All Key Events

Showing 801 to 825 of 1781 Key Events

ID	Title	Event Component Count	Biological Organization	Created At	Last Updated	AOPs

1230	TRPV1 activation, TRPV1 Short Name TRPV1 activation, TRPV1	1	Molecular	Nov 29, 2016	Dec 3, 2016	None
1231	Oxidization of biomolecules, Lipid bilayer and cellular proteins Short Name	0		Nov 29, 2016	Nov 29, 2016	None
1232	Production of nerve growth factor , Short Name Production of nerve growth factor ,	0		Nov 29, 2016	Nov 29, 2016	None
1233	Production, Nerve growth factor Short Name Production, Nerve growth factor	0		Nov 29, 2016	Nov 29, 2016	None
1234	Production of nerve growth factor , Epithelial irritation Short Name	2	Tissue	Nov 29, 2016	Dec 3, 2016	None
1235	Non-neuronal production of IL-8/CXCL1, Epithelial irritation Short Name	3	Tissue	Nov 29, 2016	Dec 3, 2016	None
1236	Generation of novel epitopes , Antigen presentation Short Name	1	Cellular	Nov 29, 2016	Dec 3, 2016	None
1237	Sensitization, Immune system Short Name Sensitization, Immune system	1	Individual	Nov 29, 2016	Dec 3, 2016	None
1238	Activation of oxidative stress pathway Short Name Oxidation	3	Molecular	Nov 29, 2016	Jun 19, 2017	None
1239	Altered, Gene Expression Short Name Altered, Gene Expression	1	Molecular	Nov 29, 2016	Mar 6, 2019	2 AOPs 200: Estrogen receptor activation leading to breast cancer 275: Histone deacetylase inhibition leads to neural tube defects
1240	Altered, Protein Production Short Name Altered, Protein Production	1	Cellular	Nov 29, 2016	Sep 16, 2017	200: Estrogen receptor activation leading to breast cancer
1241	Increased, Motility Short Name Increased, Motility	1	Cellular	Nov 29, 2016	Feb 28, 2024	2 AOPs 200: Estrogen receptor activation leading to breast cancer 439: Activation of the AhR leading to metastatic breast cancer
1242	Increased, Second Messenger Production Short Name Increased, Second Messenger Production	1	Cellular	Nov 29, 2016	Sep 16, 2017	200: Estrogen receptor activation leading to breast cancer
1243	Altered, Ca2+-calmodulin activated signal transduction Short Name	3	Cellular	Nov 29, 2016	Jun 7, 2018	4 AOPs 88: Nicotinic acetylcholine receptor activation contributes to abnormal foraging and leads to colony loss/failure via abnormal role change within caste 89: Nicotinic acetylcholine receptor activation followed by desensitization contributes to abnormal foraging and directly leads to colony loss/failure 77: Nicotinic acetylcholine receptor activation contributes to abnormal foraging and leads to colony death/failure 1 87: Nicotinic acetylcholine receptor activation contributes to abnormal foraging and leads to colony loss/failure
1244	Mucus hypersecretion, Short Name Mucus hypersecretion,	0		Nov 29, 2016	Nov 29, 2016	None
1245	Mucus , Hypersecretion Short Name Mucus , Hypersecretion	0		Nov 29, 2016	Nov 29, 2016	None
1246	Lung function, Decrease Short Name Lung function, Decrease	0		Nov 29, 2016	Nov 29, 2016	None
1247	EGFR , PPAR-alpha activation Short Name EGFR , PPAR-alpha activation	0		Nov 29, 2016	Nov 29, 2016	None
1248	EGFR , Activation Short Name EGFR , Activation	0		Nov 29, 2016	Nov 29, 2016	None
1250	Decrease, Lung function Short Name Decreased lung function	1	Individual	Nov 29, 2016	Sep 8, 2021	7 AOPs 148: EGFR Activation Leading to Decreased Lung Function 302: Lung surfactant function inhibition leading to decreased lung function 411: Oxidative stress Leading to Decreased Lung Function 418: Aryl hydrocarbon receptor activation leading to impaired lung function through AHR-ARNT toxicity pathway 419: Aryl hydrocarbon receptor activation leading to impaired lung function through P53 toxicity pathway 424: Oxidative stress Leading to Decreased Lung Function via CFTR dysfunction 425: Oxidative Stress Leading to Decreased Lung Function via Decreased FOXJ1
1251	Chronic, Mucus hypersecretion Short Name Chronic, Mucus hypersecretion	1	Tissue	Nov 29, 2016	Aug 25, 2021	None
1252	Binding to (interferes with) topoisomerase II enzyme Short Name Binding, topoisomerase II	1	Molecular	Dec 16, 2016	Aug 1, 2022	202: Inhibitor binding to topoisomerase II leading to infant leukaemia
1253	MLL chromosomal translocation Short Name MLL translocation	1	Cellular	Dec 16, 2016	Aug 1, 2022	202: Inhibitor binding to topoisomerase II leading to infant leukaemia
1254	Infant leukaemia Short Name IFL	0	Individual	Dec 16, 2016	Aug 1, 2022	202: Inhibitor binding to topoisomerase II leading to infant leukaemia
1255	induced spawning Short Name induced spawning	1	Individual	Jan 13, 2017	Jan 13, 2017	195: 5-hydroxytryptamine transporter (5-HTT) inhibition leading to population increase