AOP-Wiki

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All Key Events

Showing 1026 to 1050 of 1781 Key Events

ID	Title	Event Component Count	Biological Organization	Created At	Last Updated	AOPs

1459	Induction, Cell damage sensing Short Name Cell damage sensing	0	Molecular	Jul 26, 2017	Jul 26, 2017	None
1460	Increased Substance P (SP) by goblet cells Short Name SP release	0	Cellular	Jul 27, 2017	Jul 27, 2017	None
1461	Increase, DNA double-strand breaks Short Name Increase, DSB	0	Molecular	Aug 2, 2017	Nov 13, 2023	5 AOPs 202: Inhibitor binding to topoisomerase II leading to infant leukaemia 339: DNA methyltransferase inhibition leading to population decline (4) 330: Excessive reactive oxygen species production leading to mortality (4) 331: Formation of DNA photoproducts leading to growth inhibition (1) 338: DNA methyltransferase inhibition leading to population decline (3)
1462	Thiol group of chemicals interact with sulfuhydryl groups of proteins to form thiol adducts Short Name Thiol protein adducts	0	Molecular	Aug 3, 2017	Aug 3, 2017	242: Inhibition of lysyl oxidase leading to enhanced chronic fish toxicity
1463	Inhibition of lysyl oxidase Short Name Inhibition of lysyl oxidase	0	Cellular	Aug 3, 2017	Aug 3, 2017	242: Inhibition of lysyl oxidase leading to enhanced chronic fish toxicity
1464	Reduction of collagen crosslinking Short Name Reduction of collagen crosslinking	0	Tissue	Aug 3, 2017	Aug 3, 2017	242: Inhibition of lysyl oxidase leading to enhanced chronic fish toxicity
1465	Weak collagen matrix Short Name Weak collagen matrix	0	Tissue	Aug 3, 2017	Aug 3, 2017	242: Inhibition of lysyl oxidase leading to enhanced chronic fish toxicity
1466	Notochord distortion or malformations Short Name Notochord malformation	0	Organ	Aug 3, 2017	Aug 3, 2017	242: Inhibition of lysyl oxidase leading to enhanced chronic fish toxicity
1467	Growth, reduction Short Name Growth, reduction	0	Individual	Aug 3, 2017	Aug 3, 2017	242: Inhibition of lysyl oxidase leading to enhanced chronic fish toxicity
1468	Activation, Latent Transforming Growth Factor Beta 1 Short Name TGFbeta1 activation	0	Molecular	Aug 16, 2017	Aug 16, 2017	241: Latent Transforming Growth Factor beta1 activation leads to pulmonary fibrosis
1469	Activation, Transforming Growth Factor beta pathway Short Name TGFbeta pathway activation	0	Molecular	Aug 16, 2017	Aug 16, 2017	241: Latent Transforming Growth Factor beta1 activation leads to pulmonary fibrosis
1470	inherited mutations in offspring Short Name increase in inherited mutations	0	Individual	Aug 20, 2017	Aug 20, 2017	None
1471	Increase, Uncoupling of photophosphorylation Short Name	0	Cellular	Oct 10, 2017	Oct 10, 2017	245: Reduction in photophosphorylation leading to growth inhibition in aquatic plants
1472	Decrease, ATP production Short Name Decrease, ATP production	0	Cellular	Oct 10, 2017	Apr 11, 2021	3 AOPs 245: Reduction in photophosphorylation leading to growth inhibition in aquatic plants 386: Deposition of ionizing energy leading to population decline via inhibition of photosynthesis 389: Oxygen-evolving complex damage leading to population decline via inhibition of photosynthesis
1473	Decrease, Chlorophyll synthesis Short Name Decrease, Chlorophyll synthesis	0	Cellular	Oct 10, 2017	Oct 10, 2017	245: Reduction in photophosphorylation leading to growth inhibition in aquatic plants
1474	Decrease, Light harvest capacity Short Name Decrease, Light harvest capacity	0	Cellular	Oct 10, 2017	Oct 10, 2017	245: Reduction in photophosphorylation leading to growth inhibition in aquatic plants
1475	Decrease, Photosynthesis Short Name Decrease, Photosynthesis	0	Cellular	Oct 10, 2017	Oct 10, 2017	3 AOPs 245: Reduction in photophosphorylation leading to growth inhibition in aquatic plants 386: Deposition of ionizing energy leading to population decline via inhibition of photosynthesis 389: Oxygen-evolving complex damage leading to population decline via inhibition of photosynthesis
1476	Decrease, Glycolysis Short Name Decrease, Glycolysis	0	Cellular	Oct 10, 2017	Oct 10, 2017	245: Reduction in photophosphorylation leading to growth inhibition in aquatic plants
1477	Decrease, Oxidative phosphorylation Short Name Decrease, OXPHOS	0	Cellular	Oct 10, 2017	Dec 20, 2018	4 AOPs 245: Reduction in photophosphorylation leading to growth inhibition in aquatic plants 276: Inhibition of complex I of the electron transport chain leading to chemical induced Fanconi syndrome 328: Excessive reactive oxygen species production leading to mortality (2) 387: Deposition of ionising energy leading to population decline via mitochondrial dysfunction
1478	Decrease, Leaf cell mitosis Short Name Decrease, Leaf cell mitosis	0	Tissue	Oct 10, 2017	Oct 10, 2017	245: Reduction in photophosphorylation leading to growth inhibition in aquatic plants
1479	Decrease, Leaf development Short Name Decrease, Leaf development	0	Organ	Oct 10, 2017	Oct 10, 2017	2 AOPs 245: Reduction in photophosphorylation leading to growth inhibition in aquatic plants 389: Oxygen-evolving complex damage leading to population decline via inhibition of photosynthesis
1480	Increase, Growth hormone Short Name Increase, Growth hormone	0	Organ	Oct 10, 2017	Feb 16, 2021	None
1481	Inhibition of mitochondrial DNA polymerase gamma (Pol gamma) Short Name	0	Molecular	Oct 25, 2017	Oct 25, 2017	256: Inhibition of mitochondrial DNA polymerase gamma leading to kidney toxicity
1482	Depletion, mtDNA Short Name Depletion, mtDNA	0	Cellular	Oct 25, 2017	Oct 25, 2017	256: Inhibition of mitochondrial DNA polymerase gamma leading to kidney toxicity
1484	Receptor mediated endocytosis Short Name Receptor mediated endocytosis	0	Molecular	Oct 25, 2017	Oct 25, 2017	None