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All Key Events

Showing 1626 to 1650 of 1781 Key Events

ID	Title	Event Component Count	Biological Organization	Created At	Last Updated	AOPs

2093	Brain thyroid hormone (T4/T3) decreased Short Name Decreased brain T4/T3	0	Organ	Jan 19, 2023	Jan 19, 2023	402: Thyroid peroxidase (TPO) inhibition leads to periventricular heterotopia formation in the developing rat brain
2094	Abnormal, neuroblast migration Short Name Abnormal cell migration in brain	0	Cellular	Jan 19, 2023	Jan 19, 2023	402: Thyroid peroxidase (TPO) inhibition leads to periventricular heterotopia formation in the developing rat brain
2095	Periventricular heterotopia formation Short Name Heterotopia formation	0	Individual	Jan 19, 2023	Jan 19, 2023	402: Thyroid peroxidase (TPO) inhibition leads to periventricular heterotopia formation in the developing rat brain
2096	Occurrence, (Micro)vascular dysfunction Short Name (Micro)vascular dysfunction	4	Tissue	Jan 23, 2023	Jul 31, 2023	385: Viral spike protein interaction with ACE2 leads to microvascular dysfunction, via ACE2 dysregulation
2097	Increase, Pro-Inflammatory Mediators Short Name Increase, Pro-Inflammatory Mediators	0	Tissue	Jan 25, 2023	Mar 22, 2023	483: Deposition of Energy Leading to Learning and Memory Impairment
2098	Increase, Abnormal Neural Remodeling Short Name Abnormal Neural Remodeling	0	Tissue	Jan 25, 2023	Mar 10, 2024	483: Deposition of Energy Leading to Learning and Memory Impairment
2099	hERG channel blockade Short Name hERG channel blockade	0	Molecular	Jan 29, 2023	Jan 29, 2023	433: hERG channel blockade leading to sudden cardiac death
2100	Inhibition of rapid delayed rectifying potassium current Short Name	0	Cellular	Jan 29, 2023	Jan 29, 2023	433: hERG channel blockade leading to sudden cardiac death
2101	Conformational changes of thyroid receptor Short Name	0	Molecular	Feb 7, 2023	Feb 7, 2023	None
2102	Cytotoxicity (human trophoblast cells) Short Name Cytotoxicity (human trophoblast cells)	0	Cellular	Feb 7, 2023	Feb 7, 2023	None
2103	Cellular dysfunction (human placenta trophoblast cells) Short Name	0	Cellular	Feb 7, 2023	Feb 7, 2023	None
2104	Decreased, thyroid hormone binding to thyroid hormone receptor Short Name Decreased, TH binding to THR	0	Molecular	Feb 21, 2023	Feb 21, 2023	485: Thyroid hormone antagonism leading to impaired oligodendrocyte maturation during development and subsequent decreased cognition
2105	Decreased, myelin basic protein expression in oligodendrocytes Short Name	0	Molecular	Feb 21, 2023	Feb 21, 2023	485: Thyroid hormone antagonism leading to impaired oligodendrocyte maturation during development and subsequent decreased cognition
2106	Impaired, oligodendrocyte maturation Short Name Impaired OL maturation	0	Cellular	Feb 21, 2023	Feb 21, 2023	485: Thyroid hormone antagonism leading to impaired oligodendrocyte maturation during development and subsequent decreased cognition
2107	Hypomyelination Short Name Hypomyelination	0	Tissue	Feb 21, 2023	Feb 21, 2023	5 AOPs 485: Thyroid hormone antagonism leading to impaired oligodendrocyte maturation during development and subsequent decreased cognition 487: Unknown MIE altering cholesterol metabolism leading to decreased cognition 488: Increased reactive oxygen species production leading to decreased cognitive function 489: Inhibition of voltage-gated sodium channels leading to decreased cognition 525: Reduced oligodendrocyte differentiation during neurodevelopment leading to impaired learning and memory
2108	Altered, white brain matter Short Name Altered, white brain matter	0	Tissue	Feb 21, 2023	Feb 21, 2023	5 AOPs 485: Thyroid hormone antagonism leading to impaired oligodendrocyte maturation during development and subsequent decreased cognition 487: Unknown MIE altering cholesterol metabolism leading to decreased cognition 488: Increased reactive oxygen species production leading to decreased cognitive function 489: Inhibition of voltage-gated sodium channels leading to decreased cognition 525: Reduced oligodendrocyte differentiation during neurodevelopment leading to impaired learning and memory
2109	Binding, extracellular matrix protein laminin Short Name Binding to laminin	0	Molecular	Feb 21, 2023	Feb 21, 2023	486: Binding to the extracellular protein laminin leading to decreased cognitive function
2110	Disrupted binding, laminin-beta1-integrin receptors with laminin Short Name	0	Molecular	Feb 21, 2023	Feb 21, 2023	486: Binding to the extracellular protein laminin leading to decreased cognitive function
2111	Decreased, neural progenitor cell adhesion to laminin Short Name NPC adhesion to laminin	0	Cellular	Feb 21, 2023	Feb 21, 2023	486: Binding to the extracellular protein laminin leading to decreased cognitive function
2112	Disturbed, radial glia cell alignment and migration Short Name RG alignment and migration	0	Cellular	Feb 21, 2023	Feb 21, 2023	486: Binding to the extracellular protein laminin leading to decreased cognitive function
2113	Decreased, radial glia cell density Short Name RG density	0	Cellular	Feb 21, 2023	Feb 21, 2023	486: Binding to the extracellular protein laminin leading to decreased cognitive function
2114	Disturbed, cortical architecture Short Name Disturbed cortical architecture	0	Organ	Feb 21, 2023	Feb 21, 2023	486: Binding to the extracellular protein laminin leading to decreased cognitive function
2115	Altered, cholesterol metabolism Short Name Cholesterol metabolism	0	Molecular	Feb 22, 2023	Feb 22, 2023	2 AOPs 487: Unknown MIE altering cholesterol metabolism leading to decreased cognition 525: Reduced oligodendrocyte differentiation during neurodevelopment leading to impaired learning and memory
2116	Decreased, oligodendrocyte differentiation Short Name Oligodendrocyte differentiation	0	Cellular	Feb 22, 2023	Feb 22, 2023	3 AOPs 487: Unknown MIE altering cholesterol metabolism leading to decreased cognition 488: Increased reactive oxygen species production leading to decreased cognitive function 489: Inhibition of voltage-gated sodium channels leading to decreased cognition
2117	Increase, goblet cell number Short Name Increase, goblet cell number	1	Cellular	Mar 8, 2023	Mar 8, 2023	148: EGFR Activation Leading to Decreased Lung Function