Key Event Relationships (KERs)

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Showing 2226 to 2250 of 2767 KERs

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ID Upstream Event Downstream Event Creation Date Last Updated AOPs
3161 177: Mitochondrial dysfunction 2144: Impaired insulin signaling Mar 13, 2024 Mar 13, 2024
3164 177: Mitochondrial dysfunction 1917: Altered expression of NRF2 pathway-dependent genes Mar 14, 2024 Mar 14, 2024
3165 177: Mitochondrial dysfunction 202: Inhibition, Nuclear factor kappa B (NF-kB) Mar 14, 2024 Mar 14, 2024
2193 1816: Mitochondrial dysfunction EMPTY 1817: Apoptotic cell death Nov 2, 2020 Nov 2, 2020 None
2195 1816: Mitochondrial dysfunction EMPTY 1815: ER stress Nov 2, 2020 Nov 2, 2020 None
2499 1816: Mitochondrial dysfunction EMPTY 1392: Oxidative Stress Oct 26, 2021 Oct 26, 2021
2932 1816: Mitochondrial dysfunction EMPTY 2144: Impaired insulin signaling May 25, 2023 May 25, 2023 None
3043 1816: Mitochondrial dysfunction EMPTY 1585: Proteasomal dysfunction Sep 14, 2023 Sep 14, 2023 None
1941 1547: Mitochondrial Injury 1546: Increased reactive oxygen species (in the mitochondria) Jun 7, 2019 Jun 7, 2019 None
1942 1547: Mitochondrial Injury 889: Impaired, Proteostasis Jun 7, 2019 Jun 7, 2019 None
2715 1547: Mitochondrial Injury 1825: Increase, Cell death Jul 25, 2022 Jul 25, 2022 None
3049 1547: Mitochondrial Injury 1812: Increase, Cyt c release Sep 14, 2023 Sep 14, 2023
603 598: modulation, sodium channel 599: prolonged, Depolarization of neuronal membrane Nov 29, 2016 Dec 3, 2016
802 801: modulation, Unknown 802: Increased, HIF-1 alpha transcription Nov 29, 2016 Dec 3, 2016
2448 1912: Motile Cilia Number/Length, Decreased 1908: CBF, Decreased Jul 23, 2021 Sep 28, 2021
1563 1425: Mu Opioid Receptor Agonism 1426: Release of G Proteins Jun 8, 2017 Jun 8, 2017
2443 1909: MCC, Decreased 1250: Decreased lung function Jul 19, 2021 Mar 24, 2023
2445 1910: Mucus Viscosity, Increased 1908: CBF, Decreased Jul 19, 2021 Aug 2, 2021 None
2446 1910: Mucus Viscosity, Increased 1909: MCC, Decreased Jul 19, 2021 Aug 2, 2021 None
33 27: N/A, Androgen receptor, Antagonism 286: Altered, Transcription of genes by the AR Nov 29, 2016 Dec 3, 2016
35 27: N/A, Androgen receptor, Antagonism 310: Alteration, Wnt pathway Nov 29, 2016 Dec 3, 2016
757 764: N/A, Ataxia, paralysis, or hyperactivity 351: Increased Mortality Nov 29, 2016 Dec 3, 2016
88 75: N/A, Covalent binding to protein, possibly lysine residue 151: Activation, Inflammatory cytokines, chemokines, cytoprotective gene pathways Nov 29, 2016 Sep 24, 2020 None
1700 75: N/A, Covalent binding to protein, possibly lysine residue 398: Activation, Dendritic Cells Dec 7, 2017 Sep 24, 2020 None
136 119: N/A, Gap 49: Reduction, Ca and HCO3 transport to shell gland Nov 29, 2016 Dec 3, 2016