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All KERs

Showing 1826 to 1850 of 2767 KERs

ID	Upstream Event	Downstream Event	Creation Date	Last Updated	AOPs

1213	1161: Increased, oocyte maturation	1163: Increased, Reproductive Success	Nov 29, 2016	Dec 3, 2016	None
1328	1161: Increased, oocyte maturation	1255: induced spawning	Jan 17, 2017	Jan 17, 2017	1 AOP 195: 5-hydroxytryptamine transporter (5-HTT) inhibition leading to population increase
1128	1088: Increased, Oxidative Stress	1032: Increased, secretion of local growth factors	Nov 29, 2016	Dec 3, 2016	1 AOP 171: Chronic cytotoxicity of the serous membrane leading to pleural/peritoneal mesotheliomas in the rat.
1160	1088: Increased, Oxidative Stress	1097: Occurrence, renal proximal tubular necrosis	Nov 29, 2016	Dec 3, 2016	4 AOPs 177: Cyclooxygenase 1 (COX1) inhibition leading to renal failure and mortality 186: unknown MIE leading to renal failure and mortality 138: Organic anion transporter (OAT1) inhibition leading to renal failure and mortality 447: Kidney failure induced by inhibition of mitochondrial electron transfer chain through apoptosis, inflammation and oxidative stress pathways
1300	1088: Increased, Oxidative Stress	1194: Increase, DNA Damage	Nov 29, 2016	Dec 3, 2016	2 AOPs 200: Estrogen receptor activation leading to breast cancer 444: Ionizing radiation leads to reduced reproduction in Eisenia fetida via reduced spermatogenesis and cocoon hatchability
2385	1088: Increased, Oxidative Stress	1775: Increase, Oocyte apoptosis	May 12, 2021	May 12, 2021	1 AOP 396: Deposition of ionizing energy leads to population decline via impaired meiosis
2618	1088: Increased, Oxidative Stress	1365: Increase, Apoptosis	Mar 28, 2022	Mar 28, 2022	1 AOP 444: Ionizing radiation leads to reduced reproduction in Eisenia fetida via reduced spermatogenesis and cocoon hatchability
2933	1088: Increased, Oxidative Stress	2144: Impaired insulin signaling	May 25, 2023	May 25, 2023	1 AOP 497: ERa inactivation alters mitochondrial functions and insulin signalling in skeletal muscle and leads to insulin resistance and metabolic syndrome
2936	1088: Increased, Oxidative Stress	1816: Mitochondrial dysfunction EMPTY	May 26, 2023	May 26, 2023	None
3160	1088: Increased, Oxidative Stress	177: Mitochondrial dysfunction	Mar 13, 2024	Mar 13, 2024	1 AOP 497: ERa inactivation alters mitochondrial functions and insulin signalling in skeletal muscle and leads to insulin resistance and metabolic syndrome
1526	1399: Increased, packaged serotonin	1400: Increased, synaptic release	Jun 1, 2017	Jun 1, 2017	3 AOPs 223: Serotonin transporter activation to seizure 224: Serotonin transporter activation to depression 225: Serotonin transporter activation to agitation
1960	1665: Plasma HCY level	1666: dysfunction of microcirculation	Jul 3, 2019	Jul 3, 2019	1 AOP 301: Inhibition of Cystathionine Beta synthase leading to impaired the early development of anterior-posterior axis
776	775: Increased, Plasma tyrosine	776: Increase, Cytotoxicity (corneal cells)	Nov 29, 2016	Dec 3, 2016	1 AOP 114: HPPD inhibition leading to corneal papillomas and carcinomas (in rat)
1095	1057: Increased, PPAR-alpha activation	1058: Decreased, bile flow	Nov 29, 2016	Dec 3, 2016	1 AOP 166: PPARalpha activation leading to pancreatic acinar tumors in the rat and mouse
1096	1057: Increased, PPAR-alpha activation	1059: Increased, cholestasis	Nov 29, 2016	Dec 3, 2016	1 AOP 166: PPARalpha activation leading to pancreatic acinar tumors in the rat and mouse
1097	1057: Increased, PPAR-alpha activation	1060: Alteration, lipid metabolism	Nov 29, 2016	Dec 3, 2016	1 AOP 166: PPARalpha activation leading to pancreatic acinar tumors in the rat and mouse
595	588: Increased, predation	592: Reduced, survival	Nov 29, 2016	Dec 3, 2016	2 AOPs 91: Sodium channel inhibition leading to reduced survival 95: Ether-a-go-go (ERG) voltage-gated potassium channel inhibition leading to reduced survival
654	588: Increased, predation	636: Decreased, survival	Nov 29, 2016	Dec 3, 2016	1 AOP 99: Histamine (H2) receptor antagonism leading to reduced survival
1114	1077: Increased, prolactin exposure	1078: Hyperplasia, Mammary gland	Nov 29, 2016	Dec 3, 2016	1 AOP 168: GnRH pulse disruption leading to mammary adenomas and carcinomas in the SD rat.
1122	1084: Increased, prolactin secretion	1085: Increased, hyperplasia (mammary gland)	Nov 29, 2016	Dec 3, 2016	1 AOP 170: Anti-dopaminergic activity leading to mammary adenomas and carcinomas in the SD rat
1266	1189: Increased, Proliferation (Endothelial cells)	1213: Increased, Angiogenesis	Nov 29, 2016	Dec 20, 2022	1 AOP 200: Estrogen receptor activation leading to breast cancer
1076	1033: Increased, proliferation of mesenchymal cells	1035: Increased, Firbrosarcoma	Nov 29, 2016	Dec 3, 2016	1 AOP 163: PPARgamma activation leading to sarcomas in rats, mice, and hamsters
1077	1033: Increased, proliferation of mesenchymal cells	1036: Increased, liposarcoma	Nov 29, 2016	Dec 3, 2016	1 AOP 163: PPARgamma activation leading to sarcomas in rats, mice, and hamsters
1078	1033: Increased, proliferation of mesenchymal cells	1037: Increased, hemagiosarcoma	Nov 29, 2016	Dec 3, 2016	1 AOP 163: PPARgamma activation leading to sarcomas in rats, mice, and hamsters
343	377: Increased, Proliferation/Clonal Expansion of Mutant Cells (Pre-Neoplastic Lesions/Altered H	378: Tumorigenesis, Hepatocellular carcinoma	Nov 29, 2016	Nov 29, 2016	None

Key Event Relationships (KERs)

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