Key Event Relationships (KERs)

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Showing 1976 to 2000 of 2767 KERs

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ID Upstream Event Downstream Event Creation Date Last Updated AOPs
2907 850: Induction, CYP1A2/CYP1A5 1969: Increase, Oxidative Stress May 4, 2023 May 4, 2023
1262 1206: Induction, Doublesex1 gene 1209: Induction, Male reproductive tract Nov 29, 2016 Dec 3, 2016
386 145: Induction, IKB inhibitory protein 202: Inhibition, Nuclear factor kappa B (NF-kB) Nov 29, 2016 Dec 3, 2016
170 164: Induction, Liver “Dysfunctional” Changes by CGA 330050 147: Inhibition, Inducible Nitric Oxide Synthase by Metabolite CGA 265307 Nov 29, 2016 Dec 3, 2016
1263 1209: Induction, Male reproductive tract 1208: Increased, Male offspring Nov 29, 2016 Dec 3, 2016
859 838: Induction, Microvesicular fat 840: Formation, Liver fibrosis Nov 29, 2016 Dec 3, 2016
1518 1394: Sustained proliferation 1395: Liver Cancer May 30, 2017 Oct 9, 2020
1059 1019: Induction, pharyngeal muscle paralysis 1016: Inhibition, Feeding Nov 29, 2016 Dec 3, 2016
261 238: Induction, Pre-mature molting 328: Decrease, Fecundity Nov 29, 2016 Dec 3, 2016 None
262 238: Induction, Pre-mature molting 350: Increase, Mortality Nov 29, 2016 Dec 3, 2016 None
263 238: Induction, Pre-mature molting 351: Increased Mortality Nov 29, 2016 Dec 3, 2016 None
1050 1014: Induction, Somatic muscle paralysis 351: Increased Mortality Nov 29, 2016 Dec 3, 2016
1055 1014: Induction, Somatic muscle paralysis 1016: Inhibition, Feeding Nov 29, 2016 Dec 3, 2016
3089 1014: Induction, Somatic muscle paralysis 1015: Increased, Neuronal synaptic inhibition Oct 17, 2023 Oct 17, 2023
298 269: Induction, Sustained Cell Proliferation 347: Formation, Liver tumor Nov 29, 2016 Dec 3, 2016
299 270: Induction, Sustained Hepatotoxicity 269: Induction, Sustained Cell Proliferation Nov 29, 2016 Dec 3, 2016
2235 295: Induction, Upregulation of glucuronyltransferase activity 401: Increase, Biliary excretion TH glucuronide Dec 9, 2020 Dec 9, 2020 None
2428 295: Induction, Upregulation of glucuronyltransferase activity 1021: Increased, T4/T3 catabolism Jul 7, 2021 Jul 7, 2021 None
2478 295: Induction, Upregulation of glucuronyltransferase activity 961: Increased, Clearance of thyroxine from serum Sep 10, 2021 Sep 10, 2021
2483 295: Induction, Upregulation of glucuronyltransferase activity 281: T4 in serum, Decreased Sep 14, 2021 Sep 14, 2021 None
2884 295: Induction, Upregulation of glucuronyltransferase activity 2133: Increase, Glucuronidation of T4 Apr 12, 2023 Apr 12, 2023 None
916 901: Infiltration, Inflammatory cells 902: Inflammation, Liver Nov 29, 2016 Nov 29, 2016 None
926 907: Infiltration, Inflammatory cytokines 902: Inflammation, Liver Nov 29, 2016 Dec 3, 2016 None
1855 1599: Inflammatory events 1600: Eczematous eruption Feb 4, 2019 Feb 4, 2019 None
2916 1599: Inflammatory events 1196: Increased, Invasion May 11, 2023 May 11, 2023